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Ubiquitin

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Line 85: Line 85:
**[[5b83]] – hTetraUBB + optineurin<br />
**[[5b83]] – hTetraUBB + optineurin<br />
-
* Polyubiquitin
+
* Polyubiquitin-B
-
**[[4zpz]] – hPolyUBB-B (mutant)<br />
+
**[[4zpz]] – hUBB (mutant)<br />
-
**[[5af4]], [[4xyz]] – hPolyUBB-C <br />
+
**[[5x3o]], [[3x3m]] – hUBB + d-ubiquitin <br />
-
**[[5af5]], [[5nl4]] – hPolyUBB-C (mutant)<br />
+
**[[3phd]] – hUBB + histone deacetylase 6
-
**[[5x3o]], [[3x3m]] – hPolyUBB-B + d-ubiquitin <br />
+
**[[3znh]] – hUBB + UBB thioesterase<br />
-
**[[3phd]] – hPolyUBB+histone deacetylase 6
+
**[[5ydr]] – hUBB + DNMT1<br />
-
**[[3znh]] – hPolyUBB-B + UBB thioesterase<br />
+
**[[6fdk]] – hUBB + DUB1<br />
-
**[[4uf6]] – hPolyUBB-B + UCH-L5 + NF-κ-b-related protein<br />
+
**[[6ei1]], [[6fge]] – hUBB + ZUP1<br />
-
**[[5vf0]] – hPolyUBB-B + RAD18 - NMR<br />
+
**[[6cp2]] – hUBB + UBCH7 + SIDC<br />
-
**[[5vey]] – hPolyUBB-B + RNF169 + Histone H2A-H2B - NMR<br />
+
**[[6bva]], [[6byh]], [[6c16]] – hUBB + SKP1 + FBL10<br />
-
**[[5n38]] , [[5n2w]] – hPolyUBB-B + E3 UBB protein ligase PARKIN<br />
+
**[[4uf6]] – hUBB + UCH-L5 + NF-κ-b-related protein<br />
-
**[[5mnj]] – hPolyUBB-B + E3 UBB protein ligase MDM2 + UBCH5B<br />
+
**[[5vf0]] – hUBB + RAD18 - NMR<br />
-
**[[5l8w]] – hPolyUBB-B + WD repeat-containing protein 48 + USP12<br />
+
**[[5vey]] – hUBB + RNF169 + Histone H2A-H2B - NMR<br />
-
**[[5l8h]] – hPolyUBB-B + WD repeat-containing protein 48 + USP46<br />
+
**[[5n38]] , [[5n2w]], [[6glc]] – hUBB + E3 UBB protein ligase PARKIN<br />
-
**[[5kyf]], [[5kye]], [[5kyd]], [[5kyc]] – hPolyUBB-B + USP7<br />
+
**[[6fx4]] – hUBB (mutant) + E3 UBB protein ligase SMURF2<br />
-
**[[3znz]] – hPolyUBB-C + otulin<br />
+
**[[5mnj]] – hUBB + E3 UBB protein ligase MDM2 + UBCH5B<br />
-
**[[4jqw]] – hPolyUBB-C + NOD1 CARD<br />
+
**[[5l8w]] – hUBB + WD repeat-containing protein 48 + USP12<br />
-
**[[4k1r]] – hPolyUBB-C + SST2<br />
+
**[[5l8h]] – hUBB + WD repeat-containing protein 48 + USP46<br />
-
**[[5oe7]] – hPolyUBB-C + otulin<br />
+
**[[5kyf]], [[5kye]], [[5kyd]], [[5kyc]] – hUBB + USP7<br />
 +
**[[6ftx]] – hUBB + histones H4+H2A+H2B+H3.3C + DNA - Cryo EM<br />
 +
 
 +
* Polyubiquitin-C
 +
 
 +
**[[5af4]], [[4xyz]] – hUBC <br />
 +
**[[5af5]], [[5nl4]] – hUBC (mutant)<br />
 +
**[[3znz]] – hUBC + otulin<br />
 +
**[[4jqw]] – hUBC + NOD1 CARD<br />
 +
**[[4k1r]] – hUBC + SST2<br />
 +
**[[5oe7]] – hUBC + otulin<br />
 +
**[[6b7m]], [[6b70]] – hUBC + SDED<br />
 +
**[[6aqr]] – hUBC + SAGA + UBP8 + SGF11 + SUS1 + SGF73<br />
* Ubiquitin monomer bound to protein
* Ubiquitin monomer bound to protein

Revision as of 17:14, 2 October 2018

Human ubiquitin (green) complex with ubiquitin-conjugating enzyme E2 (deep sky blue), 3k9p

Drag the structure with the mouse to rotate

3D Structures of Ubiquitin

Updated on 02-October-2018

References

  1. ↑ Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem. 1998;67:425-79. PMID:9759494 doi:http://dx.doi.org/10.1146/annurev.biochem.67.1.425
  2. ↑ Paul S. Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches. Bioessays. 2008 Nov;30(11-12):1172-84. doi: 10.1002/bies.20852. PMID:18937370 doi:http://dx.doi.org/10.1002/bies.20852
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