Ubiquitin activating enzyme

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<StructureSection load='1y8x' size='350' side='right' caption='Structure of human ubiquitin activating enzyme Uba3 subunit (green) complex with E2 Ubc12 (grey) (PDB entry [[1y8x]])' scene=''>
<StructureSection load='1y8x' size='350' side='right' caption='Structure of human ubiquitin activating enzyme Uba3 subunit (green) complex with E2 Ubc12 (grey) (PDB entry [[1y8x]])' scene=''>
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'''Ubiquitin activating enzyme''' (Uba) or '''E1 enzyme''' catalyzes the first step in the ubiquitination of a protein tagged to be degraded by the proteasome. Ubiquitin activating enzyme (E1) and ATP produce a C-terminal acyl adenylated ubiquitin molecule which binds to ubiquitin conjugating enzyme (E2) (Ubc) cysteine<ref>PMID:7673335</ref>. The Ubc then binds to ubiquitin ligase (E3) via a conserved binding region. E3 catalyzes the transfer of ubiquitin from the Ubc-ubiquitin complex to a lysine residue of the target protein. '''Uba3''' is the catalytic subunit of NEDD8 activating enzyme and APPB1 is its regulatory subunit. Similar to ubiquitin and SUMO, NEDD8 binds to proteins after processing of its C-terminal. '''SUMO-activating enzyme subunit 2''' (SAE2) is involved in sumoylation of proteins.<br />
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'''Ubiquitin activating enzyme''' (Uba) or '''E1 enzyme''' catalyzes the first step in the ubiquitination of a protein tagged to be degraded by the proteasome. Ubiquitin activating enzyme (E1) and ATP produce a C-terminal acyl adenylated ubiquitin molecule which binds to ubiquitin conjugating enzyme (E2) (Ubc) cysteine<ref>PMID:7673335</ref>. The Ubc then binds to ubiquitin ligase (E3) via a conserved binding region. E3 catalyzes the transfer of ubiquitin from the Ubc-ubiquitin complex to a lysine residue of the target protein. '''Uba3''' is the catalytic subunit of NEDD8 activating enzyme and APPB1 is its regulatory subunit. Similar to ubiquitin and SUMO, NEDD8 binds to proteins after processing of its C-terminal. <br />
For more details on Uba1 see [[Uba1]].
For more details on Uba1 see [[Uba1]].
</StructureSection>
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Revision as of 19:28, 2 October 2018

Structure of human ubiquitin activating enzyme Uba3 subunit (green) complex with E2 Ubc12 (grey) (PDB entry 1y8x)

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3D Structures of ubiquitin activating enzyme

Updated on 02-October-2018

References

  1. ↑ Nagai Y, Kaneda S, Nomura K, Yasuda H, Seno T, Yamao F. Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2. J Cell Sci. 1995 Jun;108 ( Pt 6):2145-52. PMID:7673335

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Michal Harel, Alexander Berchansky

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