2bt4
From Proteopedia
| Line 32: | Line 32: | ||
[[Category: shikimate pathway]] | [[Category: shikimate pathway]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 17:48:05 2007'' |
Revision as of 15:42, 5 November 2007
|
TYPE II DEHYDROQUINASE INHIBITOR COMPLEX
Overview
Selective inhibitors of type II dehydroquinase were rationally designed to, explore a second binding-pocket in the active-site. The molecular, modelling, synthesis, inhibition studies and crystal structure, determination are described.
About this Structure
2BT4 is a Single protein structure of sequence from Streptomyces coelicolor with PO4, CA2, TRS and GOL as ligands. Active as 3-dehydroquinate dehydratase, with EC number 4.2.1.10 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:16106291
Page seeded by OCA on Mon Nov 5 17:48:05 2007
Categories: 3-dehydroquinate dehydratase | Single protein | Streptomyces coelicolor | Abell, C. | Coggins, J.R. | Lapthorn, A.J. | Stewart, K.A. | Toscano, M.D. | CA2 | GOL | PO4 | TRS | Amino-acid biosynthesis | Aromatic amino acid biosynthesis | Dehydroquinase | Dehydroquinate | Drug design | Lyase | Shikimate pathway
