5yad
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Marf1 Lotus domain from Mus musculus== | |
| - | + | <StructureSection load='5yad' size='340' side='right' caption='[[5yad]], [[Resolution|resolution]] 1.76Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yad]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yad OCA], [http://pdbe.org/5yad PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yad RCSB], [http://www.ebi.ac.uk/pdbsum/5yad PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yad ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MARF1_MOUSE MARF1_MOUSE]] Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks.<ref>PMID:22442484</ref> <ref>PMID:23090997</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ma, J B]] | ||
| + | [[Category: Wu, B X]] | ||
| + | [[Category: Yao, Q Q]] | ||
| + | [[Category: Lotus domain]] | ||
| + | [[Category: Marf1]] | ||
| + | [[Category: Meiosis]] | ||
| + | [[Category: Rna binding]] | ||
| + | [[Category: Rna binding protein]] | ||
Revision as of 07:37, 3 October 2018
Crystal structure of Marf1 Lotus domain from Mus musculus
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Categories: Ma, J B | Wu, B X | Yao, Q Q | Lotus domain | Marf1 | Meiosis | Rna binding | Rna binding protein
