6a96

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m (Protected "6a96" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6a96 is ON HOLD
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==Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25==
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<StructureSection load='6a96' size='340' side='right' caption='[[6a96]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
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Authors: Liu, S., Xu, L., Guan, F., Liu, Y.T., Cui, Y., Zhang, Q., Bi, G.Q., Zhou, Z.H., Zhang, X., Ye, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6a96]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A96 FirstGlance]. <br>
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Description: Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a96 OCA], [http://pdbe.org/6a96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a96 RCSB], [http://www.ebi.ac.uk/pdbsum/6a96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a96 ProSAT]</span></td></tr>
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[[Category: Bi, G.Q]]
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</table>
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[[Category: Ye, S]]
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== Disease ==
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[[Category: Zhou, Z.H]]
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[[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
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__TOC__
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</StructureSection>
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[[Category: Bi, G Q]]
[[Category: Cui, Y]]
[[Category: Cui, Y]]
[[Category: Guan, F]]
[[Category: Guan, F]]
[[Category: Liu, S]]
[[Category: Liu, S]]
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[[Category: Liu, Y T]]
[[Category: Xu, L]]
[[Category: Xu, L]]
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[[Category: Liu, Y.T]]
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[[Category: Ye, S]]
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[[Category: Zhang, Q]]
[[Category: Zhang, X]]
[[Category: Zhang, X]]
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[[Category: Zhang, Q]]
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[[Category: Zhou, Z H]]
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[[Category: Iron channel]]
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[[Category: Membrane protein]]

Revision as of 07:42, 3 October 2018

Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25

6a96, resolution 3.51Å

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