6a96
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25== | |
- | + | <StructureSection load='6a96' size='340' side='right' caption='[[6a96]], [[Resolution|resolution]] 3.51Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[6a96]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A96 FirstGlance]. <br> | |
- | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
- | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a96 OCA], [http://pdbe.org/6a96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a96 RCSB], [http://www.ebi.ac.uk/pdbsum/6a96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a96 ProSAT]</span></td></tr> |
- | [[ | + | </table> |
- | [[ | + | == Disease == |
- | [[Category: | + | [[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry. |
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Bi, G Q]] | ||
[[Category: Cui, Y]] | [[Category: Cui, Y]] | ||
[[Category: Guan, F]] | [[Category: Guan, F]] | ||
[[Category: Liu, S]] | [[Category: Liu, S]] | ||
+ | [[Category: Liu, Y T]] | ||
[[Category: Xu, L]] | [[Category: Xu, L]] | ||
- | [[Category: | + | [[Category: Ye, S]] |
+ | [[Category: Zhang, Q]] | ||
[[Category: Zhang, X]] | [[Category: Zhang, X]] | ||
- | [[Category: | + | [[Category: Zhou, Z H]] |
+ | [[Category: Iron channel]] | ||
+ | [[Category: Membrane protein]] |
Revision as of 07:42, 3 October 2018
Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25
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Categories: Bi, G Q | Cui, Y | Guan, F | Liu, S | Liu, Y T | Xu, L | Ye, S | Zhang, Q | Zhang, X | Zhou, Z H | Iron channel | Membrane protein