6cga
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the PR-DUB complex== | |
| - | + | <StructureSection load='6cga' size='340' side='right' caption='[[6cga]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6cga]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CGA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cga OCA], [http://pdbe.org/6cga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cga RCSB], [http://www.ebi.ac.uk/pdbsum/6cga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cga ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CALYP_DROME CALYP_DROME]] Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:20436459</ref> [[http://www.uniprot.org/uniprot/ASX_DROME ASX_DROME]] Atypical Polycomb group protein, which may be involved in both Polycomb group (PcG) and trithorax group (trxG) complexes. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PcG and trxG proteins act by forming multiprotein complexes, which are respectively required to maintain the transcriptionally repressive and transcriptionally active state of homeotic genes throughout development. PcG and trxG protein complexes are not required to initiate repression and activation, but to maintain it during later stages of development.<ref>PMID:20436459</ref> <ref>PMID:9477319</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ubiquitinyl hydrolase 1]] | ||
| + | [[Category: Day, C L]] | ||
| + | [[Category: Foglizzo, M]] | ||
| + | [[Category: Mace, P D]] | ||
| + | [[Category: Middleton, A J]] | ||
| + | [[Category: Dub complex]] | ||
| + | [[Category: Hetero-tetramer]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Nucleosome binding protein]] | ||
Revision as of 07:46, 3 October 2018
Structure of the PR-DUB complex
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