6dlk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of DNA polymerase III subunit beta from Rickettsia rickettsii== | |
| - | + | <StructureSection load='6dlk' size='340' side='right' caption='[[6dlk]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6dlk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DLK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlk OCA], [http://pdbe.org/6dlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dlk RCSB], [http://www.ebi.ac.uk/pdbsum/6dlk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlk ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A0A0H3AWV3_RICRS A0A0H3AWV3_RICRS]] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[PIRNR:PIRNR000804] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Dna polymerase iii beta]] | ||
| + | [[Category: Dnan]] | ||
| + | [[Category: Potential drug target]] | ||
| + | [[Category: Sliding clamp]] | ||
| + | [[Category: Ssgcid]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:47, 3 October 2018
Crystal structure of DNA polymerase III subunit beta from Rickettsia rickettsii
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