6f2i

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'''Unreleased structure'''
 
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The entry 6f2i is ON HOLD
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==Crystal structure of Hen Egg-White Lysozyme co-crystallized in presence of 100 mM Tb-Xo4==
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<StructureSection load='6f2i' size='340' side='right' caption='[[6f2i]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6f2i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F2I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7MT:1,4-Bis((6-carboxypyridin-2-yl)methyl)-1,4,7-triazacyclononane'>7MT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f2i OCA], [http://pdbe.org/6f2i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f2i RCSB], [http://www.ebi.ac.uk/pdbsum/6f2i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f2i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystallophores are lanthanide complexes that act as powerful auxiliary for protein crystallography due to their strong nucleating and phasing effects. To get first insights on the mechanisms behind nucleation induced by Crystallophore, we systematically identified various elaborated networks of supramolecular interactions between Tb-Xo4 and subset of 6 protein structures determined by X-ray diffraction in complex with terbium-Crystallophore (Tb-Xo4). Such interaction mapping analyses demonstrate the versatile binding behavior of the Crystallophore and pave the way to a better understanding of its unique properties.
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Authors: Engilberge, S., Riobe, F., DI Pietro, S., Girard, E., Dumont, E., Maury, O.
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Unveiling the Binding Modes of the Crystallophore, a Terbium-based Nucleating and Phasing Molecular Agent for Protein Crystallography.,Engilberge S, Riobe F, Wagner T, Di Pietro S, Breyton C, Franzetti B, Shima S, Girard E, Dumont E, Maury O Chemistry. 2018 Jul 11;24(39):9739-9746. doi: 10.1002/chem.201802172. Epub 2018, Jun 25. PMID:29806881<ref>PMID:29806881</ref>
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Description: Crystal structure of Hen Egg-White Lysozyme co-crystallized in presence of 100 mM Tb-Xo4
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Maury, O]]
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<div class="pdbe-citations 6f2i" style="background-color:#fffaf0;"></div>
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[[Category: Girard, E]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
[[Category: Dumont, E]]
[[Category: Dumont, E]]
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[[Category: Di Pietro, S]]
 
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[[Category: Riobe, F]]
 
[[Category: Engilberge, S]]
[[Category: Engilberge, S]]
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[[Category: Girard, E]]
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[[Category: Maury, O]]
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[[Category: Pietro, S DI]]
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[[Category: Riobe, F]]
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[[Category: Crystallophore]]
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[[Category: Hydrolase]]
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[[Category: Lanthanide complex]]
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[[Category: Nucleation]]
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[[Category: Phasing]]
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[[Category: Tb-xo4]]

Revision as of 07:50, 3 October 2018

Crystal structure of Hen Egg-White Lysozyme co-crystallized in presence of 100 mM Tb-Xo4

6f2i, resolution 1.20Å

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