6mhs
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human TRPV3 channel in a putative sensitized conformation== | |
| - | + | <StructureSection load='6mhs' size='340' side='right' caption='[[6mhs]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mhs]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MHS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mhs OCA], [http://pdbe.org/6mhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mhs RCSB], [http://www.ebi.ac.uk/pdbsum/6mhs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mhs ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN]] Mutilating palmoplantar keratoderma with periorificial keratotic plaques. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
| - | [[Category: Lander, G | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).<ref>PMID:12077604</ref> <ref>PMID:12077606</ref> <ref>PMID:21593771</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Borschel, W F]] | ||
| + | [[Category: Herzik, M A]] | ||
| + | [[Category: Hirschi, M]] | ||
| + | [[Category: Lander, G C]] | ||
| + | [[Category: Lee, S Y]] | ||
[[Category: Song, A]] | [[Category: Song, A]] | ||
| - | [[Category: Hirschi, M]] | ||
[[Category: Wu, M]] | [[Category: Wu, M]] | ||
| - | [[Category: | + | [[Category: Zubcevic, L]] |
| - | [[Category: | + | [[Category: Calcium transport]] |
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transport protein]] | ||
| + | [[Category: Trp channel]] | ||
Revision as of 07:56, 3 October 2018
Structure of the human TRPV3 channel in a putative sensitized conformation
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