5n2l
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='5n2l' size='340' side='right' caption='[[5n2l]], [[Resolution|resolution]] 1.89Å' scene=''> | <StructureSection load='5n2l' size='340' side='right' caption='[[5n2l]], [[Resolution|resolution]] 1.89Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5n2l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2L FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5n2l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2L FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8J2:propan-2-yl+~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate'>8J2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8J2:propan-2-yl+~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate'>8J2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD2, KIAA9001, RING3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2l OCA], [http://pdbe.org/5n2l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2l RCSB], [http://www.ebi.ac.uk/pdbsum/5n2l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2l ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2l OCA], [http://pdbe.org/5n2l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2l RCSB], [http://www.ebi.ac.uk/pdbsum/5n2l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | [[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein|Bromodomain-containing protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bharatham, N]] | [[Category: Bharatham, N]] | ||
Revision as of 08:26, 3 October 2018
Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue
| |||||||||||
Categories: Human | Arrowsmith, C H | Bharatham, N | Bountra, C | Boyd, V A | Chai, S | Chen, T | Delft, F von | Edwards, A M | Fedorov, O | Guy, R K | Heroven, C | Knapp, S | Krojer, T | Lee, R E | Picaud, S | Structural genomic | Shadrick, W R | Shelat, A A | Siejka, P | Slavish, P J | Tallant, C | Wiggers, H J | Young, B M | Sgc | Transcription
