6h5n
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='6h5n' size='340' side='right' caption='[[6h5n]], [[Resolution|resolution]] 3.23Å' scene=''> | <StructureSection load='6h5n' size='340' side='right' caption='[[6h5n]], [[Resolution|resolution]] 3.23Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6h5n]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H5N FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6h5n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H5N FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h5n OCA], [http://pdbe.org/6h5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h5n RCSB], [http://www.ebi.ac.uk/pdbsum/6h5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h5n ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF45/48, PFS45-48, PFS45/48, PF13_0247 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h5n OCA], [http://pdbe.org/6h5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h5n RCSB], [http://www.ebi.ac.uk/pdbsum/6h5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h5n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/P4548_PLAF7 P4548_PLAF7]] Gametocyte surface protein required for male fertility. | [[http://www.uniprot.org/uniprot/P4548_PLAF7 P4548_PLAF7]] Gametocyte surface protein required for male fertility. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The quest to develop an effective malaria vaccine remains a major priority in the fight against global infectious disease. An approach with great potential is a transmission-blocking vaccine which induces antibodies that prevent establishment of a productive infection in mosquitos that feed on infected humans, thereby stopping the transmission cycle. One of the most promising targets for such a vaccine is the gamete surface protein, Pfs48/45. Here we establish a system for production of full-length Pfs48/45 and use this to raise a panel of monoclonal antibodies. We map the binding regions of these antibodies on Pfs48/45 and correlate the location of their epitopes with their transmission-blocking activity. Finally, we present the structure of the C-terminal domain of Pfs48/45 bound to the most potent transmission-blocking antibody, and provide key molecular information for future structure-guided immunogen design. | ||
| + | |||
| + | Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody.,Lennartz F, Brod F, Dabbs R, Miura K, Mekhaiel D, Marini A, Jore MM, Sogaard MM, Jorgensen T, de Jongh WA, Sauerwein RW, Long CA, Biswas S, Higgins MK Nat Commun. 2018 Sep 20;9(1):3822. doi: 10.1038/s41467-018-06340-9. PMID:30237518<ref>PMID:30237518</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6h5n" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Buffalo rat]] | ||
| + | [[Category: Plaf7]] | ||
[[Category: Higgins, M K]] | [[Category: Higgins, M K]] | ||
[[Category: Lennartz, F]] | [[Category: Lennartz, F]] | ||
[[Category: Cell invasion]] | [[Category: Cell invasion]] | ||
[[Category: Pfs48/45 gamete fusion plasmodium falciparum transmission blocking monoclonal antibody]] | [[Category: Pfs48/45 gamete fusion plasmodium falciparum transmission blocking monoclonal antibody]] | ||
Current revision
Plasmodium falciparum Pfs48/45 C-terminal domain bound to monoclonal antibody 85RF45.1
| |||||||||||
