Sandbox RDE-1

RDE-1 (RNAi-DEfective 1) is a primary Argonaute protein required for RNA-mediated interference (RNAi) in Caenorhabditis elegans. The rde-1 gene locus was first characterized in C. elegans mutants resistant to RNAi, and is a member of a highly conserved Piwi gene family that includes plant, Drosophila, and vertebrate homologs.

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Function

<a href="https://commons.wikimedia.org/wiki/File:Exogenous_RNAi_Pathway_in_C._elegans,_edited.svg#/media/File:Exogenous_RNAi_Pathway_in_C._elegans,_edited.svg"><img src="" alt="Exogenous RNAi Pathway in C. elegans, edited.svg"></a>
By <a href="//commons.wikimedia.org/w/index.php?title=User:Rli2014&action=edit&redlink=1" class="new" title="User:Rli2014 (page does not exist)">Richard Li</a> - Own work, <a href="https://creativecommons.org/licenses/by-sa/3.0" title="Creative Commons Attribution-Share Alike 3.0">CC BY-SA 3.0</a>, <a href="https://commons.wikimedia.org/w/index.php?curid=27881639">Link</a>

Disease

Relevance

Structural highlights

Canonical Argonaute proteins possess three primary domains forming a crescent-shaped base: the PAZ, MID, and PIWI domains. PAZ and MID orient and anchor the double-stranded siRNA by binding to the 3’ and 5’ termini, respectively, leaving the internal nucleotides accessible for base pairing. The PIWI domain folds into an RNase H-like structure, and contains the conserved catalytic triad “DDH” (two aspartate residues, one histidine residue).[9] The crystal structure of RDE-1 has not been formally elucidated, but can be assumed to closely resemble its human homologs.

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