Undecaprenyl pyrophosphate synthase

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<StructureSection load='1x07' size='450' side='right' caption='Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code [[1x07]]).' scene='59/591995/Cv/4' pspeed='8'>
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<StructureSection load='1x07' size='350' side='right' caption='Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code [[1x07]]).' scene='59/591995/Cv/4' pspeed='8'>
== Function ==
== Function ==
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**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br />
**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br />
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**[[3qas]], [[5cqb]] – EcUPP – ''Escherichia coli''<br />
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**[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – EcUPP – ''Escherichia coli''<br />
**[[1jp3]] – EcUPP (mutant) <br />
**[[1jp3]] – EcUPP (mutant) <br />
**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br />
**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br />
**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br />
**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br />
**[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br />
**[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br />
 +
**[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br />
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**[[5xk3]] – StUPP – ''Streptmyces''<br />
*Undecaprenyl pyrophosphate synthase complexes
*Undecaprenyl pyrophosphate synthase complexes
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**[[1ueh]] – EcUPP + Mg + SO4 + triton<br />
**[[1ueh]] – EcUPP + Mg + SO4 + triton<br />
**[[1v7u]] – EcUPP + FPP <br />
**[[1v7u]] – EcUPP + FPP <br />
 +
**[[4u82]] – EcUPP + Mg + FPP derivative<br />
**[[1x06]] – EcUPP + Mg + FPP analog + IPP<br />
**[[1x06]] – EcUPP + Mg + FPP analog + IPP<br />
**[[1x08]] – EcUPP (mutant) + Mg + FPP analog + IPP<br />
**[[1x08]] – EcUPP (mutant) + Mg + FPP analog + IPP<br />
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**[[2vg2]] – MtUPP + Pi + PPi + methyl butenyl diphosphate <br />
**[[2vg2]] – MtUPP + Pi + PPi + methyl butenyl diphosphate <br />
**[[2vg3]] – MtUPP + Pi + Mg + geranyl diphosphate <br />
**[[2vg3]] – MtUPP + Pi + Mg + geranyl diphosphate <br />
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**[[5xk8]] – StUPP + GPP <br />
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**[[5xk6]] – StUPP + IPP <br />
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**[[5xk7]] – StUPP + DMAPP <br />
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**[[5xk9]] – StUPP + GSPP + DMAPP <br />
}}
}}

Revision as of 21:28, 4 October 2018

Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07).

Drag the structure with the mouse to rotate

3D structures of undecaprenyl pyrophosphate synthase

Updated on 04-October-2018

References

  1. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
  2. ↑ Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
  3. ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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