UvrABC
From Proteopedia
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| - | <StructureSection load='3pih' size=' | + | <StructureSection load='3pih' size='3 |
| + | 50' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' > | ||
== Function == | == Function == | ||
'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> | '''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> | ||
| - | * '''UvrA''' is the protein which locates the DNA damage.<br /> | + | * '''UvrA''' is the protein which locates the DNA damage<ref>PMID:21240268</ref>.<br /> |
* '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br /> | * '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br /> | ||
* The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>. | * The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>. | ||
Revision as of 18:36, 5 October 2018
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3D structures of UvrABC
Updated on 05-October-2018
References
- ↑ Moolenaar GF, Moorman C, Goosen N. Role of the Escherichia coli nucleotide excision repair proteins in DNA replication. J Bacteriol. 2000 Oct;182(20):5706-14. PMID:11004168
- ↑ Jaciuk M, Nowak E, Skowronek K, Tanska A, Nowotny M. Structure of UvrA nucleotide excision repair protein in complex with modified DNA. Nat Struct Mol Biol. 2011 Feb;18(2):191-7. Epub 2011 Jan 16. PMID:21240268 doi:10.1038/nsmb.1973
- ↑ Theis K, Skorvaga M, Machius M, Nakagawa N, Van Houten B, Kisker C. The nucleotide excision repair protein UvrB, a helicase-like enzyme with a catch. Mutat Res. 2000 Aug 30;460(3-4):277-300. PMID:10946234
- ↑ Moolenaar GF, Uiterkamp RS, Zwijnenburg DA, Goosen N. The C-terminal region of the Escherichia coli UvrC protein, which is homologous to the C-terminal region of the human ERCC1 protein, is involved in DNA binding and 5'-incision. Nucleic Acids Res. 1998 Jan 15;26(2):462-8. PMID:9421501
- ↑ Jaciuk M, Nowak E, Skowronek K, Tanska A, Nowotny M. Structure of UvrA nucleotide excision repair protein in complex with modified DNA. Nat Struct Mol Biol. 2011 Feb;18(2):191-7. Epub 2011 Jan 16. PMID:21240268 doi:10.1038/nsmb.1973
