Variable lymphocyte receptor

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*Variable lymphocyte receptor
*Variable lymphocyte receptor
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**[[3m19]], [[3g39]], [[2r9u]], [[3wo9]], [[4k5u]], [[4k79]] - mlVLR ectodomain – marine lamprey<br />
+
**[[3m19]], [[4k5u]], [[4k79]] - mlVLR ectodomain – marine lamprey<br />
-
**[[3m18]], [[3g3a]] – mlVLR ectodomain + lysozyme<br />
+
**[[3g39]] - mlVLR B.2D ectodomain<br />
-
**[[3g3b]] - mlVLR ectodomain (mutant) + lysozyme<br />
+
**[[3g3a]] – mlVLR B.2D ectodomain + lysozyme<br />
-
**[[3e6j]] - mlVLR ectodomain + trisaccharide<br />
+
**[[3g3b]] - mlVLR B.20 ectodomain (mutant) + lysozyme<br />
-
**[[2o6q]], [[2o6r]], [[2o6s]] – IhVLR leucine-rich repeat – inshore hagfish<br />
+
**[[3m18]] – mlVLR A.R2 ectodomain + lysozyme<br />
 +
**[[2o6q]], [[2o6r]], [[2o6s]] – IhVLR A29 leucine-rich repeat – inshore hagfish<br />
**[[3twi]] – VLR B antigen-binding domain + BCLA protein – ''Bacillus anthracis''<br />
**[[3twi]] – VLR B antigen-binding domain + BCLA protein – ''Bacillus anthracis''<br />
 +
**[[2r9u]] - mlVLR 2913 ectodomain<br />
 +
**[[3wo9]] - mlVLR C ectodomain<br />
 +
**[[6bxd]] - mlVLR 2 ectodomain<br />
 +
**[[6bxe]] - mlVLR 9 ectodomain<br />
 +
**[[5wk4]] - mlVLR 39 ectodomain<br />
 +
**[[5ufb]] - mlVLR TN4-22 ectodomain<br />
 +
**[[5ufc]] - mlVLR TN4-22 ectodomain + trisaccharide<br />
 +
**[[5ufd]] - mlVLR RBC36 ectodomain<br />
 +
**[[5uff]] - mlVLR RBC36 ectodomain + bisaccharide<br />
 +
**[[3e6j]] - mlVLR RBC36 ectodomain + trisaccharide<br />
 +
**[[5uei]], [[5uf4]] - mlVLR O13 ectodomain<br />
 +
**[[5uf1]] - mlVLR O13 ectodomain + trisaccharide<br />
 +
**[[4po4]] - VLR C ectodomain - ''Lampetra planeri''<br />
*Variable lymphocyte receptor chimera
*Variable lymphocyte receptor chimera

Revision as of 19:21, 5 October 2018

Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) (3g3a), resolution 2.20Å

Drag the structure with the mouse to rotate

3D structures of variable lymphocyte receptor

Updated on 05-October-2018

Articles in Proteopedia concerning Variable lymphocyte receptors include:

Additional Literature

  • Bajoghli B, Guo P, Aghaallaei N, Hirano M, Strohmeier C, McCurley N, Bockman DE, Schorpp M, Cooper MD, Boehm T. A thymus candidate in lampreys. Nature. 2011 Feb 3;470(7332):90-4. PMID:21293377 doi:10.1038/nature09655
  • Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
  • Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z. Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates. Biol Chem. 2010 Jul;391(7):753-60. PMID:20482318 doi:10.1515/BC.2010.091
  • Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291 doi:10.1038/nsmb.1619
  • Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
  • Herrin BR, Alder MN, Roux KH, Sina C, Ehrhardt GR, Boydston JA, Turnbough CL Jr, Cooper MD. Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2040-5. Epub 2008 Jan 31. PMID:18238899 doi:10.1073/pnas.0711619105
  • Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science. 2008 Sep 26;321(5897):1834-7. PMID:18818359 doi:321/5897/1834
See Lamprey Variable Lymphocyte Receptor for details.

References

  1. ↑ Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264 doi:10.1074/jbc.M608471200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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