Sandbox nd111
From Proteopedia
(Difference between revisions)
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| - | ==Tacrine Binding Site== | + | <scene name='79/793833/Hydrophobic_tacrine/1'>Text To Be Displayed</scene>==Tacrine Binding Site== |
<StructureSection load='1acj' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1acj' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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== Active Site == | == Active Site == | ||
| - | <scene name='79/793833/Acetylcholinesterase/1'>Acetylcholinesterase</scene> can be bound by the small molecule Tacrine | + | <scene name='79/793833/Acetylcholinesterase/1'>Acetylcholinesterase</scene> can be bound by the small molecule Tacrine <scene name='79/793833/Hydrophobic_tacrine/1'>Tacrine</scene> is held in place by two hydrophobic amino acids, W89 and F330. |
== Relevance == | == Relevance == | ||
Revision as of 14:05, 8 October 2018
==Tacrine Binding Site==
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
