2qu4
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qu4 OCA], [http://www.ebi.ac.uk/pdbsum/2qu4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qu4 RCSB]</span> | ||
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[[Category: structural protein]] | [[Category: structural protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:53:18 2008'' |
Revision as of 01:53, 31 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Model for Bacterial ParM Filament
Overview
Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit interfaces. These interfaces result in the helical handedness of the ParM filament being opposite to that of F-actin. Like F-actin, ParM filaments have a variable twist, and we show that this involves domain-domain rotations within the ParM subunit. The present results yield new insights into polymorphisms within F-actin, as well as the evolution of polymer families.
About this Structure
2QU4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The structure of bacterial ParM filaments., Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH, Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:17873883
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