5zop

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'''Unreleased structure'''
 
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The entry 5zop is ON HOLD until Apr 13 2020
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==Crystal structure of histone deacetylase 4 (HDAC4) in complex with a SMRT corepressor SP2 fragment==
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<StructureSection load='5zop' size='340' side='right' caption='[[5zop]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors: Park, S.Y., Hwang, H.J., Kim, J.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5zop]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZOP FirstGlance]. <br>
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Description: Crystal structure of histone deacetylase 4 (HDAC4) in complex with a SMRT corepressor SP2 fragment
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_deacetylase Histone deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.98 3.5.1.98] </span></td></tr>
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[[Category: Kim, J.S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zop OCA], [http://pdbe.org/5zop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zop RCSB], [http://www.ebi.ac.uk/pdbsum/5zop PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zop ProSAT]</span></td></tr>
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[[Category: Park, S.Y]]
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</table>
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[[Category: Hwang, H.J]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN]] Defects in HDAC4 are the cause of brachydactyly-mental retardation syndrome (BDMR) [MIM:[http://omim.org/entry/600430 600430]]. A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism.<ref>PMID:20691407</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN]] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.<ref>PMID:10523670</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Histone deacetylase]]
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[[Category: Hwang, H J]]
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[[Category: Kim, J S]]
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[[Category: Park, S Y]]
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[[Category: Hydrolase]]
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[[Category: Protein-peptide complex]]

Revision as of 08:01, 10 October 2018

Crystal structure of histone deacetylase 4 (HDAC4) in complex with a SMRT corepressor SP2 fragment

5zop, resolution 2.70Å

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