6a7v

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m (Protected "6a7v" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6a7v is ON HOLD
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==Crystal structure of Mycobacterium tuberculosis VapBC11 toxin-antitoxin complex==
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<StructureSection load='6a7v' size='340' side='right' caption='[[6a7v]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6a7v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A7V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A7V FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a7v OCA], [http://pdbe.org/6a7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a7v RCSB], [http://www.ebi.ac.uk/pdbsum/6a7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a7v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/VPC11_MYCTU VPC11_MYCTU]] Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in E.coli and M.smegmatis inhibits translation, cell growth and colony formation. Its toxic effects on cell growth and colony formation are neutralized by coexpression with cognate antitoxin VapB11; the effect on translation has not been tested but is probably also neutralized.<ref>PMID:19016878</ref> <ref>PMID:20011113</ref> [[http://www.uniprot.org/uniprot/VPB11_MYCTU VPB11_MYCTU]] Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin VapC11.<ref>PMID:19016878</ref> <ref>PMID:20011113</ref> <ref>PMID:15718296</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Deep, A]]
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[[Category: Thakur, K G]]
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[[Category: Endoribonuclease]]
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[[Category: Rv1560-rv1561]]
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[[Category: Toxin]]
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[[Category: Toxin-antitoxin complex]]
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[[Category: Trnase]]
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[[Category: Vapbc]]

Revision as of 08:02, 10 October 2018

Crystal structure of Mycobacterium tuberculosis VapBC11 toxin-antitoxin complex

6a7v, resolution 1.67Å

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