6b8k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human galectin-3 CRD in complex with Lactulose== | |
| - | + | <StructureSection load='6b8k' size='340' side='right' caption='[[6b8k]], [[Resolution|resolution]] 1.28Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6b8k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B8K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=W9T:4-O-BETA-D-GALACTOPYRANOSYL-BETA-D-FRUCTOFURANOSE'>W9T</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8k OCA], [http://pdbe.org/6b8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b8k RCSB], [http://www.ebi.ac.uk/pdbsum/6b8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8k ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Blanchard, H]] | [[Category: Blanchard, H]] | ||
[[Category: Kishor, C]] | [[Category: Kishor, C]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 08:04, 10 October 2018
Crystal structure of Human galectin-3 CRD in complex with Lactulose
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