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6b94
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human galectin-1 in complex with Lactulose== | |
| - | + | <StructureSection load='6b94' size='340' side='right' caption='[[6b94]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6b94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B94 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=W9T:4-O-BETA-D-GALACTOPYRANOSYL-BETA-D-FRUCTOFURANOSE'>W9T</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b94 OCA], [http://pdbe.org/6b94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b94 RCSB], [http://www.ebi.ac.uk/pdbsum/6b94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b94 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Blanchard, H]] | [[Category: Blanchard, H]] | ||
[[Category: Kishor, C]] | [[Category: Kishor, C]] | ||
| + | [[Category: Galectin-1]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 08:04, 10 October 2018
Crystal structure of Human galectin-1 in complex with Lactulose
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