1vtg
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vtg OCA], [http://pdbe.org/1vtg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vtg RCSB], [http://www.ebi.ac.uk/pdbsum/1vtg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vtg ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vtg OCA], [http://pdbe.org/1vtg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vtg RCSB], [http://www.ebi.ac.uk/pdbsum/1vtg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vtg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The molecular structure of triostin A, a cyclic octadepsipeptide antibiotic, has been solved complexed to a DNA double helical fragment with the sequence CGTACG (C, cytosine; G, guanine; T, thymine; A, adenine). The two planar quinoxaline rings of triostin A bis intercalate on the minor groove of the DNA double helix surrounding the CG base pairs at either end. The alanine residues form hydrogen bonds to the guanines. Base stacking in the DNA is perturbed, and the major binding interaction involves a large number of van der Waals contacts between the peptides and the nucleic acid. The adenine residues in the center are in the syn conformation and are paired to thymine through Hoogsteen base pairing. | ||
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| + | The molecular structure of a DNA-triostin A complex.,Wang AH, Ughetto G, Quigley GJ, Hakoshima T, van der Marel GA, van Boom JH, Rich A Science. 1984 Sep 14;225(4667):1115-21. PMID:6474168<ref>PMID:6474168</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 1vtg" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:18, 10 October 2018
THE MOLECULAR STRUCTURE OF A DNA-TRIOSTIN A COMPLEX
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