2r2w
From Proteopedia
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|PDB= 2r2w |SIZE=350|CAPTION= <scene name='initialview01'>2r2w</scene>, resolution 2.01Å | |PDB= 2r2w |SIZE=350|CAPTION= <scene name='initialview01'>2r2w</scene>, resolution 2.01Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=4PG:1-[4-(2-OXO-2-PHENYLETHYL)PHENYL]GUANIDINE'>4PG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span> |
|GENE= PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2w OCA], [http://www.ebi.ac.uk/pdbsum/2r2w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r2w RCSB]</span> | ||
}} | }} | ||
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[[Category: U-plasminogen activator]] | [[Category: U-plasminogen activator]] | ||
[[Category: Zeslawska, E.]] | [[Category: Zeslawska, E.]] | ||
| - | [[Category: 4PG]] | ||
| - | [[Category: SO4]] | ||
[[Category: egf-like domain]] | [[Category: egf-like domain]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
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[[Category: urokinase]] | [[Category: urokinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:56:00 2008'' |
Revision as of 01:56, 31 March 2008
| |||||||
| , resolution 2.01Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | PLAU (Homo sapiens) | ||||||
| Activity: | U-plasminogen activator, with EC number 3.4.21.73 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Urokinase plasminogen activator B-chain-GPPE complex
Contents |
Overview
Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two different environments was determined in order to compare the binding geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a target for anti-cancer drugs. It was shown that the conformation and the hydrogen-bonding formation by GPPE molecule are similar in both environments, but several important differences were discovered and described.
Disease
Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]
About this Structure
2R2W is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Geometry of GPPE binding to picrate and to the urokinase type plasminogen activator., Zeslawska E, Sturzebecher J, Oleksyn BJ, Bioorg Med Chem Lett. 2007 Nov 15;17(22):6212-5. Epub 2007 Sep 8. PMID:17905583
Page seeded by OCA on Mon Mar 31 04:56:00 2008
