2ra4
From Proteopedia
(New page: 200px {{Structure |PDB= 2ra4 |SIZE=350|CAPTION= <scene name='initialview01'>2ra4</scene>, resolution 1.70Å |SITE= <scene name='pdbsite=AC1:So4+Binding+Site+...) |
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|PDB= 2ra4 |SIZE=350|CAPTION= <scene name='initialview01'>2ra4</scene>, resolution 1.70Å | |PDB= 2ra4 |SIZE=350|CAPTION= <scene name='initialview01'>2ra4</scene>, resolution 1.70Å | ||
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+76'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+77'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+B+76'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+77'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+A+78'>AC5</scene>, <scene name='pdbsite=AC6:So4+Binding+Site+For+Residue+B+78'>AC6</scene> and <scene name='pdbsite=AC7:Tfa+Binding+Site+For+Residue+B+79'>AC7</scene> | |SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+76'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+77'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+B+76'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+77'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+A+78'>AC5</scene>, <scene name='pdbsite=AC6:So4+Binding+Site+For+Residue+B+78'>AC6</scene> and <scene name='pdbsite=AC7:Tfa+Binding+Site+For+Residue+B+79'>AC7</scene> | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETYL+GROUP'>TFA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= CCL13, MCP4, NCC1, SCYA13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= CCL13, MCP4, NCC1, SCYA13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ra4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ra4 OCA], [http://www.ebi.ac.uk/pdbsum/2ra4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ra4 RCSB]</span> | ||
}} | }} | ||
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[[Category: Barinka, C.]] | [[Category: Barinka, C.]] | ||
[[Category: Lubkowski, J.]] | [[Category: Lubkowski, J.]] | ||
| - | [[Category: SO4]] | ||
| - | [[Category: TFA]] | ||
[[Category: cc chemokine family]] | [[Category: cc chemokine family]] | ||
[[Category: ccl13]] | [[Category: ccl13]] | ||
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[[Category: secreted]] | [[Category: secreted]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:04 2008'' |
Revision as of 01:58, 31 March 2008
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| , resolution 1.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , and | ||||||
| Ligands: | , | ||||||
| Gene: | CCL13, MCP4, NCC1, SCYA13 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)
Overview
Monocyte chemoattractant proteins (MCPs) belong to the CC chemokine family and are involved in many (patho)physiological processes characterized by mononuclear cell infiltration, including tissue remodeling, atherosclerosis and cancer metastasis. Here, the crystal structure of human monocyte chemoattractant protein 4 (MCP-4) refined at 1.70 A resolution is reported with crystallographic values R = 0.180 and R(free) = 0.212. The overall MCP-4 fold reveals the typical tertiary features of the CC chemokine family. A central three-stranded antiparallel beta-sheet is C-terminally flanked by an overlaying alpha-helix, while the N-terminal part of the molecule forms an extended loop that is anchored to the rest of the molecule via two disulfide bridges, Cys11-Cys35 and Cys12-Cys51. The crystal packing suggests the existence of MCP-4 dimers with a dimerization interface similar to those previously reported for the X-ray structures of MCP-1 and MCP-2.
About this Structure
2RA4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13)., Barinka C, Prahl A, Lubkowski J, Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):273-8. Epub 2008, Feb 20. PMID:18323622
Page seeded by OCA on Mon Mar 31 04:58:04 2008
