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6dah

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'''Unreleased structure'''
 
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The entry 6dah is ON HOLD until Paper Publication
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==2.5 Angstrom crystal structure of the N97S CaM mutant==
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<StructureSection load='6dah' size='340' side='right' caption='[[6dah]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Wang, K., Van Petegem, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6dah]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DAH FirstGlance]. <br>
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Description: 2.5 Angstrom crystal structure of the N97S CaM mutant
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dah OCA], [http://pdbe.org/6dah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dah RCSB], [http://www.ebi.ac.uk/pdbsum/6dah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dah ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[[http://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN]] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Petegem, F Van]]
[[Category: Wang, K]]
[[Category: Wang, K]]
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[[Category: Van Petegem, F]]
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[[Category: Calcium binding protein]]
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[[Category: Calmodulin]]
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[[Category: Mutant]]

Revision as of 07:57, 17 October 2018

2.5 Angstrom crystal structure of the N97S CaM mutant

6dah, resolution 2.50Å

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