6g85

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m (Protected "6g85" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6g85 is ON HOLD
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==Structure of Cdc14 bound to CBK1 PxL motif==
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<StructureSection load='6g85' size='340' side='right' caption='[[6g85]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
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Authors: Mouilleron, S., Kataria, M., Uhlmann, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6g85]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G85 FirstGlance]. <br>
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Description: A PxL motif conveys timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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[[Category: Uhlmann, F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g85 OCA], [http://pdbe.org/6g85 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g85 RCSB], [http://www.ebi.ac.uk/pdbsum/6g85 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g85 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CDC14_YEAST CDC14_YEAST]] Protein phosphatase which antagonizes mitotic cyclin-dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases. Allows damaged actomyosin rings to be maintained to facilitate completion of cell division in response to minor perturbation of the cell division machinery. Inhibits transcription of ribosomal genes (rDNA) during anaphase and controls segregation of nucleolus by facilitating condensin targeting to rDNA chromatin in anaphase. Dephosphorylates SIC1, a CDC28 inhibitor, and SWI5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator of mitotic cyclin degradation, CDH1. Dephosphorylates the microtubule bundling factor ASE1 which is required to define a centered and focused mitotic spindle midzone that can drive continuous spindle elongation. Dephosphorylates the anaphase-promoting complex inhibitor ACM1, leading to its degradation. Facilitates INN1-CYK3 complex formation which promotes cytokinesis through the dephosphosprylation of CDC28-phosphosphorylated INN1. Reverts also the inhibitory CDC28 phosphorylation of CHS2 for endoplasmic reticulum export, ensuring that septum formation is contingent upon chromosome separation and exit from mitosis. Additional substrates for CDC14 are the formins BNI1 and BNR1, as well as CDC6, DBP2, DSN1, INCENP, KAR9, MCM3, ORC2, ORC6, SLD2, and SWI6. Activity is inhibited by interaction with NET1 which sequesters it to the nucleolus.<ref>PMID:11511359</ref> <ref>PMID:12737806</ref> <ref>PMID:14993267</ref> <ref>PMID:15004526</ref> <ref>PMID:15137939</ref> <ref>PMID:15190202</ref> <ref>PMID:15917648</ref> <ref>PMID:17116692</ref> <ref>PMID:18235228</ref> <ref>PMID:18287090</ref> <ref>PMID:18595708</ref> <ref>PMID:19158678</ref> <ref>PMID:19339280</ref> <ref>PMID:20619650</ref> <ref>PMID:20660629</ref> <ref>PMID:20923974</ref> <ref>PMID:20980394</ref> <ref>PMID:21127052</ref> <ref>PMID:21690308</ref> <ref>PMID:21784165</ref> <ref>PMID:22072794</ref> <ref>PMID:22078879</ref> <ref>PMID:22117071</ref> <ref>PMID:22363215</ref> <ref>PMID:22454527</ref> <ref>PMID:22872148</ref> <ref>PMID:7021319</ref> <ref>PMID:8668128</ref> <ref>PMID:9295359</ref> <ref>PMID:9885559</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Protein-tyrosine-phosphatase]]
[[Category: Kataria, M]]
[[Category: Kataria, M]]
[[Category: Mouilleron, S]]
[[Category: Mouilleron, S]]
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[[Category: Uhlmann, F]]
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[[Category: Cbk1]]
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[[Category: Cdc14]]
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[[Category: Cell cycle]]
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[[Category: Phosphatase]]
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[[Category: Pxl]]

Revision as of 08:06, 17 October 2018

Structure of Cdc14 bound to CBK1 PxL motif

6g85, resolution 1.53Å

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