6gdl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Calmodulin mutant - F141L apo-form Unstructured C-domain== |
| - | + | <StructureSection load='6gdl' size='340' side='right' caption='[[6gdl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gdl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GDL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gdl OCA], [http://pdbe.org/6gdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gdl RCSB], [http://www.ebi.ac.uk/pdbsum/6gdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gdl ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN]] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Holt, C]] | ||
| + | [[Category: Overgaard, M T]] | ||
| + | [[Category: Wimmer, R]] | ||
| + | [[Category: Calcium signalling]] | ||
| + | [[Category: Calmodulin]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 08:06, 17 October 2018
Calmodulin mutant - F141L apo-form Unstructured C-domain
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