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2rcu

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|PDB= 2rcu |SIZE=350|CAPTION= <scene name='initialview01'>2rcu</scene>, resolution 1.78&Aring;
|PDB= 2rcu |SIZE=350|CAPTION= <scene name='initialview01'>2rcu</scene>, resolution 1.78&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene> and <scene name='pdbligand=BUJ:(3R)-3-(hexadecanoylamino)-4-(trimethylammonio)butanoate'>BUJ</scene>
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|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=BUJ:(3R)-3-(HEXADECANOYLAMINO)-4-(TRIMETHYLAMMONIO)BUTANOATE'>BUJ</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span>
|GENE= Cpt2, Cpt-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
|GENE= Cpt2, Cpt-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
 +
|DOMAIN=
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|RELATEDENTRY=[[2deb|2DEB]], [[2fw3|2FW3]], [[2fyo|2FYO]], [[2h4t|2H4T]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcu OCA], [http://www.ebi.ac.uk/pdbsum/2rcu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rcu RCSB]</span>
}}
}}
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[[Category: Rufer, A C.]]
[[Category: Rufer, A C.]]
[[Category: Thoma, R.]]
[[Category: Thoma, R.]]
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[[Category: BOG]]
 
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[[Category: BUJ]]
 
[[Category: acetylation]]
[[Category: acetylation]]
[[Category: acyltransferase]]
[[Category: acyltransferase]]
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[[Category: transport]]
[[Category: transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:34:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:56 2008''

Revision as of 01:58, 31 March 2008

Image:2rcu.gif


PDB ID 2rcu

Drag the structure with the mouse to rotate
, resolution 1.78Å
Ligands: ,
Gene: Cpt2, Cpt-2 (Rattus norvegicus)
Activity: Carnitine O-palmitoyltransferase, with EC number 2.3.1.21
Related: 2DEB, 2FW3, 2FYO, 2H4T


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of rat carnitine palmitoyltransferase 2 in complex with r-3-(hexadecanoylamino)-4-(trimethylazaniumyl)butanoate


Overview

The mitochondrial membrane-associated carnitine palmitoyltransferase system is a validated target for the treatment of type 2 diabetes mellitus. To further facilitate structure-based drug discovery, we determined the crystal structure of rat CPT-2 (rCPT-2) in complex with the substrate analogue palmitoyl-aminocarnitine at 1.8A resolution. Biochemical analyses revealed a strong effect of this compound on rCPT-2 activity and stability. Using a computational approach we examined the membrane association of rCPT-2. The protein interacts with the membrane as a functional monomer and the calculations confirm the presence of a membrane association domain that consists of layers of hydrophobic and positively charged residues.

About this Structure

2RCU is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog., Rufer AC, Lomize A, Benz J, Chomienne O, Thoma R, Hennig M, FEBS Lett. 2007 Jul 10;581(17):3247-52. Epub 2007 Jun 8. PMID:17585909

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