2rf2

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|PDB= 2rf2 |SIZE=350|CAPTION= <scene name='initialview01'>2rf2</scene>, resolution 2.4&Aring;
|PDB= 2rf2 |SIZE=350|CAPTION= <scene name='initialview01'>2rf2</scene>, resolution 2.4&Aring;
|SITE= <scene name='pdbsite=AC1:Mrx+Binding+Site+For+Residue+A+561'>AC1</scene>
|SITE= <scene name='pdbsite=AC1:Mrx+Binding+Site+For+Residue+A+561'>AC1</scene>
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|LIGAND= <scene name='pdbligand=MRX:'>MRX</scene>
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|LIGAND= <scene name='pdbligand=MRX:5-BROMO-3-(PYRROLIDIN-1-YLSULFONYL)-1H-INDOLE-2-CARBOXAMIDE'>MRX</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf2 OCA], [http://www.ebi.ac.uk/pdbsum/2rf2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rf2 RCSB]</span>
}}
}}
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[[Category: Prasad, S.]]
[[Category: Prasad, S.]]
[[Category: Yan, Y.]]
[[Category: Yan, Y.]]
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[[Category: MRX]]
 
[[Category: aid]]
[[Category: aid]]
[[Category: ai]]
[[Category: ai]]
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[[Category: zinc-finger]]
[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:35:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:38 2008''

Revision as of 01:59, 31 March 2008

Image:2rf2.jpg


PDB ID 2rf2

Drag the structure with the mouse to rotate
, resolution 2.4Å
Sites:
Ligands:
Gene: gag-pol (Human immunodeficiency virus 1)
Activity: RNA-directed DNA polymerase, with EC number 2.7.7.49
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)


Overview

This Letter describes the design, synthesis, and biological evaluation of novel 3-indole sulfonamides as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) with balanced profiles against common HIV RT mutants K103N and Y181C.

About this Structure

2RF2 is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)., Zhao Z, Wolkenberg SE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, Lindsley CW, Hartman GD, Vacca JP, Williams TM, Bioorg Med Chem Lett. 2008 Jan 15;18(2):554-9. Epub 2007 Nov 28. PMID:18083561

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