2rfn
From Proteopedia
(Difference between revisions)
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|PDB= 2rfn |SIZE=350|CAPTION= <scene name='initialview01'>2rfn</scene>, resolution 2.50Å | |PDB= 2rfn |SIZE=350|CAPTION= <scene name='initialview01'>2rfn</scene>, resolution 2.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=AM7:2- | + | |LIGAND= <scene name='pdbligand=AM7:2-BENZYL-5-(3-FLUORO-4-{[6-METHOXY-7-(3-MORPHOLIN-4-YLPROPOXY)QUINOLIN-4-YL]OXY}PHENYL)-3-METHYLPYRIMIDIN-4(3H)-ONE'>AM7</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span> |
|GENE= MET ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= MET ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2rfs|2RFS]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rfn OCA], [http://www.ebi.ac.uk/pdbsum/2rfn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rfn RCSB]</span> | ||
}} | }} | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]] |
==About this Structure== | ==About this Structure== | ||
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[[Category: Yang, Y.]] | [[Category: Yang, Y.]] | ||
[[Category: Zhang, Y.]] | [[Category: Zhang, Y.]] | ||
| - | [[Category: AM7]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
[[Category: c-met hgf receptor tyrosine kinse kinase domain]] | [[Category: c-met hgf receptor tyrosine kinse kinase domain]] | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:00:01 2008'' |
Revision as of 02:00, 31 March 2008
| |||||||
| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | MET (Homo sapiens) | ||||||
| Activity: | Receptor protein-tyrosine kinase, with EC number 2.7.10.1 | ||||||
| Related: | 2RFS
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
x-ray structure of c-Met with inhibitor.
Disease
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]
About this Structure
2RFN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Page seeded by OCA on Mon Mar 31 05:00:01 2008
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Single protein | Bellon, S F. | Dussault, I. | Kaplan-Lefko, P. | Moriguchi, J. | Yang, Y. | Zhang, Y. | Atp-binding | C-met hgf receptor tyrosine kinse kinase domain | Glycoprotein | Membrane | Nucleotide-binding | Phosphorylation | Proto-oncogene | Transferase | Transmembrane | Tyrosine-protein kinase
