2rip
From Proteopedia
(Difference between revisions)
(New page: 200px {{Structure |PDB= 2rip |SIZE=350|CAPTION= <scene name='initialview01'>2rip</scene>, resolution 2.90Å |SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+...) |
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|PDB= 2rip |SIZE=350|CAPTION= <scene name='initialview01'>2rip</scene>, resolution 2.90Å | |PDB= 2rip |SIZE=350|CAPTION= <scene name='initialview01'>2rip</scene>, resolution 2.90Å | ||
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+1085'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+2085'>AC2</scene>, <scene name='pdbsite=AC3:Man+Binding+Site+For+Residue+A+3085'>AC3</scene>, <scene name='pdbsite=AC4:Man+Binding+Site+For+Residue+A+4085'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+4086'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+A+4087'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Residue+A+1219'>AC7</scene>, <scene name='pdbsite=AC8:Nag+Binding+Site+For+Residue+A+1229'>AC8</scene>, <scene name='pdbsite=AC9:Nag+Binding+Site+For+Residue+A+1281'>AC9</scene>, <scene name='pdbsite=BC1:Nag+Binding+Site+For+Residue+A+1321'>BC1</scene> and <scene name='pdbsite=BC2:34q+Binding+Site+For+Residue+A+800'>BC2</scene> | |SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+1085'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+2085'>AC2</scene>, <scene name='pdbsite=AC3:Man+Binding+Site+For+Residue+A+3085'>AC3</scene>, <scene name='pdbsite=AC4:Man+Binding+Site+For+Residue+A+4085'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+4086'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+A+4087'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Residue+A+1219'>AC7</scene>, <scene name='pdbsite=AC8:Nag+Binding+Site+For+Residue+A+1229'>AC8</scene>, <scene name='pdbsite=AC9:Nag+Binding+Site+For+Residue+A+1281'>AC9</scene>, <scene name='pdbsite=BC1:Nag+Binding+Site+For+Residue+A+1321'>BC1</scene> and <scene name='pdbsite=BC2:34q+Binding+Site+For+Residue+A+800'>BC2</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=34Q:(3R,4R)-4-(PYRROLIDIN-1-YLCARBONYL)-1-(QUINOXALIN-2-YLCARBONYL)PYRROLIDIN-3-AMINE'>34Q</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span> |
|GENE= DPPIV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= DPPIV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rip OCA], [http://www.ebi.ac.uk/pdbsum/2rip PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rip RCSB]</span> | ||
}} | }} | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
| - | [[Category: 34Q]] | ||
| - | [[Category: NAG]] | ||
[[Category: aminopeptidase]] | [[Category: aminopeptidase]] | ||
[[Category: diabetes]] | [[Category: diabetes]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:00:55 2008'' |
Revision as of 02:00, 31 March 2008
| |||||||
| , resolution 2.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , , , , and | ||||||
| Ligands: | , , | ||||||
| Gene: | DPPIV (Homo sapiens) | ||||||
| Activity: | Dipeptidyl-peptidase IV, with EC number 3.4.14.5 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of DPPIV in complex with an inhibitor
Overview
The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD profile. An X-ray co-crystal structure of 5 confirmed the proposed mode of binding. The potent single digit DPP-IV inhibitor 53 exhibited a preferred PK/PD profile in preclinical animal models and was selected for additional profiling.
About this Structure
2RIP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors., Corbett JW, Dirico K, Song W, Boscoe BP, Doran SD, Boyer D, Qiu X, Ammirati M, Vanvolkenburg MA, McPherson RK, Parker JC, Cox ED, Bioorg Med Chem Lett. 2007 Dec 15;17(24):6707-13. Epub 2007 Oct 22. PMID:17977724
Page seeded by OCA on Mon Mar 31 05:00:55 2008
