RNA polymerase

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Line 53: Line 53:
**[[3h0g]] – SpRNAP II<br />
**[[3h0g]] – SpRNAP II<br />
**[[3ayh]] - SpRNAP III subunit Rpc8+Rpc9<br />
**[[3ayh]] - SpRNAP III subunit Rpc8+Rpc9<br />
-
**[[4kbj]] – RNAP β subunit – ''Mycobacterium tuberculosis''<br />
+
**[[4kbj]] – MtuRNAP β subunit – ''Mycobacterium tuberculosis''<br />
 +
**[[5uh7]] - MtuRNAP subunit β’<br />
**[[4noi]] – RNAP α subunit – ''Campylobacter jejuni''<br />
**[[4noi]] – RNAP α subunit – ''Campylobacter jejuni''<br />
**[[1hqm]] – TaRNAP subunits α,β,β’,ω − ''Thermus aquaticus''<br />
**[[1hqm]] – TaRNAP subunits α,β,β’,ω − ''Thermus aquaticus''<br />
Line 73: Line 74:
**[[3q22]], [[3q23]], [[3q24]], [[4ff1]], [[4ff2]], [[4ff3]], [[4ff4]] – RNAP + DNA – Enterobacteria phage N4<br />
**[[3q22]], [[3q23]], [[3q24]], [[4ff1]], [[4ff2]], [[4ff3]], [[4ff4]] – RNAP + DNA – Enterobacteria phage N4<br />
**[[2o5i]], [[2o5j]], [[4gzy]], [[4gzz]], [[4xln]], [[4xlr]] - TtRNAP subunits α,β,β’,ω + DNA +RNA<br />
**[[2o5i]], [[2o5j]], [[4gzy]], [[4gzz]], [[4xln]], [[4xlr]] - TtRNAP subunits α,β,β’,ω + DNA +RNA<br />
 +
**[[5x22]] - TtRNAP subunits α,β,β’,ω + DNA + RNA + CMPCPP<br />
 +
**[[5x21]] - TtRNAP subunits α,β,β’,ω + DNA + RNA + antibiotic<br />
**[[4wqs]], [[4xlp]], [[4xlq]], [[4xls]], [[5tjg]] - TtRNAP subunits α,β,β’,ω + DNA<br />
**[[4wqs]], [[4xlp]], [[4xlq]], [[4xls]], [[5tjg]] - TtRNAP subunits α,β,β’,ω + DNA<br />
**[[2ppb]] - TtRNAP subunits α,β,β’,ω + antibiotic + DNA + RNA + substrate analog<br />
**[[2ppb]] - TtRNAP subunits α,β,β’,ω + antibiotic + DNA + RNA + substrate analog<br />
**[[4yg2]], [[4jk1]], [[4jk2]], [[4jkr]], [[4kmu]] - EcRNAP subunits α,β,β’,ω + RNA<br />
**[[4yg2]], [[4jk1]], [[4jk2]], [[4jkr]], [[4kmu]] - EcRNAP subunits α,β,β’,ω + RNA<br />
 +
**[[6flp]], [[6bjs]], [[6asx]], [[6alh]], [[6alf]] - EcRNAP subunits α,β,β’,ω RNA + DNA – Cryo EM<br />
**[[4kn4]], [[4kn7]] - EcRNAP subunits α,β,β’,ω + RNA + antibiotic<br />
**[[4kn4]], [[4kn7]] - EcRNAP subunits α,β,β’,ω + RNA + antibiotic<br />
Line 91: Line 95:
**[[4oip]] - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA + nucleotide<br />
**[[4oip]] - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA + nucleotide<br />
**[[4oiq]], [[4oir]] - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA + antibiotic<br />
**[[4oiq]], [[4oir]] - TtRNAP subunits α,β,β’,ω + σ factor + GE23077 + DNA + antibiotic<br />
-
**[[4g7h]], [[4g7o]], [[4g7z]], [[4q4z]], [[5d4d]], [[5d4e]] - TtRNAP subunits α,β,β’,ω + σ factor + DNA<br />
+
**[[4g7h]], [[4g7o]], [[4g7z]], [[4q4z]], [[5d4d]], [[5d4e]], [[5voi]] - TtRNAP subunits α,β,β’,ω + σ factor + DNA<br />
-
**[[4q5s]], [[5d4c]], [[5e17]], [[5e18]] - TtRNAP subunits α,β,β’,ω + σ factor + DNA + RNA<br />
+
**[[4q5s]], [[5d4c]], [[5e17]], [[5e18]], [[5vo8]] - TtRNAP subunits α,β,β’,ω + σ factor + DNA + RNA<br />
-
**[[5i2d]] - TtRNAP subunits α,β,β’,ω + factor + transcriptional regulator + DNA + RNA<br />
+
**[[5i2d]] - TtRNAP subunits α,β,β’,ω + σ factor + transcriptional regulator + DNA + RNA<br />
**[[3dxj]], [[3eql]] - TtRNAP subunits α,β,β’,ω + σ factor + antibiotic<br />
**[[3dxj]], [[3eql]] - TtRNAP subunits α,β,β’,ω + σ factor + antibiotic<br />
 +
**[[6cuu]] - TtRNAP subunits α,β,β’,ω + σ factor + DNA + antibiotic<br />
 +
**[[5xj0]] - TtRNAP subunits α,β,β’,ω + σ factor + GP39 + GP76<br />
**[[4wqt]] - TtRNAP subunits α,β,β’,ω + RNA cleavage stimulating factor<br />
**[[4wqt]] - TtRNAP subunits α,β,β’,ω + RNA cleavage stimulating factor<br />
**[[3mlq]] - TtRNAP subunit β + transcription-repair coupling factor<br />
**[[3mlq]] - TtRNAP subunit β + transcription-repair coupling factor<br />
Line 105: Line 111:
**[[5ciz]] - EcRNAP subunit α + DNA + CRP<br />
**[[5ciz]] - EcRNAP subunit α + DNA + CRP<br />
**[[3n97]] - EcRNAP subunit α C terminal + DNA + σ factor<br />
**[[3n97]] - EcRNAP subunit α C terminal + DNA + σ factor<br />
-
**[[4ljz]], [[4lk1]], [[4mey]], [[4xsx]], [[4xsy]], [[4xsz]], [[4zh2]], [[4zh3]] , [[4zh4]], [[5byh]], [[5nwt]], [[5uag]], [[5uah]], [[5uaj]], [[5ual]], [[5uaq]] - EcRNAP subunits α,β,β’,ω + σ factor <br />
+
**[[4ljz]], [[4lk1]], [[4mey]], [[4xsx]], [[4xsy]], [[4xsz]], [[4zh2]], [[4zh3]] , [[4zh4]], [[5byh]], [[5nwt]], [[5uag]], [[5uah]], [[5uaj]], [[5ual]], [[5uaq]], [[5ui8]] - EcRNAP subunits α,β,β’,ω + σ factor <br />
-
**[[5nsr]], [[5nss]] - EcRNAP subunits α,β,β’,ω + sigma factor + DNA – Cryo EMbr />
+
**[[6c9y]] - EcRNAP subunits α,β,β’,ω + σ factor – Cryo EM<br />
-
**[[4yln]], [[4ylo]], [[4ylp]], [[5ipl]], [[5ipm]], [[5ipn]] - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + DNA + RNA<br />
+
**[[5nsr]], [[5nss]], [[6gh6]], [[6gh5]], [[6ca0]] - EcRNAP subunits α,β,β’,ω + σ factor + DNA – Cryo EM<br />
 +
**[[5vt0]] - EcRNAP subunits α,β,β’,ω + σ factor + RNA – Cryo EM<br />
 +
**[[4yln]], [[4ylo]], [[4ylp]], [[5ipl]], [[5ipm]], [[5ipn]], [[6gfw]] - EcRNAP subunits α,β,β’,ω + σ factor + DNA + RNA<br />
 +
**[[6b6h]] - EcRNAP subunits α,β,β’,ω + σ factor + CAP + DNA + RNA – Cryo EM<br />
**[[4mex]] - EcRNAP subunits α,β,β’,ω + σ factor + salinamide<br />
**[[4mex]] - EcRNAP subunits α,β,β’,ω + σ factor + salinamide<br />
**[[4lk0]], [[4llg]], [[4mex]], [[4yfk]], [[4yfn]], [[4yfx]] - EcRNAP subunits α,β,β’,ω + σ factor + RNAP inhibitor<br />
**[[4lk0]], [[4llg]], [[4mex]], [[4yfk]], [[4yfn]], [[4yfx]] - EcRNAP subunits α,β,β’,ω + σ factor + RNAP inhibitor<br />
-
**[[5uac]] - EcRNAP subunits α,β,β’,ω + sigma factor + rifampin<br />
+
**[[5uac]], [[6cux]] - EcRNAP subunits α,β,β’,ω + σ factor + antibiotic<br />
 +
**[[6byu]] - EcRNAP subunits α,β,β’,ω + σ factor + PPAPP<br />
 +
**[[5w1s]] - EcRNAP subunits α,β,β’,ω + σ factor + TRAR<br />
**[[3iyd]] - EcRNAP subunits α,β,β’,ω + σ factor + catabolite gene activator + DNA<br />
**[[3iyd]] - EcRNAP subunits α,β,β’,ω + σ factor + catabolite gene activator + DNA<br />
**[[4s20]] - EcRNAP subunits α,β,β’,ω + σ factor + RAPA + DNA<br />
**[[4s20]] - EcRNAP subunits α,β,β’,ω + σ factor + RAPA + DNA<br />
**[[5tbz]] - EcRNAP subunits α,β,β’ + NusG – Cryo EM<br />
**[[5tbz]] - EcRNAP subunits α,β,β’ + NusG – Cryo EM<br />
-
**[[5ms0]] - EcRNAP subunits α,β,β’,ω + sigma factor + NusB + NusG + NusA + antitermination protein + DNA – Cryo EM<br />
+
**[[6c6u]] - EcRNAP subunits α,β,β’,ω + NusG + DNA – Cryo EM<br />
-
**[[3ihq]], [[1z3e]], [[3gfk]] - BsRNAP subunit α +regulatory protein SPX
+
**[[6c6t]], [[6c6s]] - EcRNAP subunits α,β,β’,ω + RFAH + DNA – Cryo EM<br />
 +
**[[5ms0]] - EcRNAP subunits α,β,β’,ω + σ factor + NusB + NusG + NusA + antitermination protein + RS10 + DNA – Cryo EM<br />
 +
**[[6flq]] - EcRNAP subunits α,β,β’,ω + NusA + DNA + RNA – Cryo EM<br />
 +
**[[6alg]] - EcRNAP subunits α,β,β’,ω + NUN + DNA + RNA – Cryo EM<br />
 +
**[[6fbv]] - MtuRNAP subunits α,β,β’,ω + σ factor – single particle EM<br />
 +
**[[5uha]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA <br />
 +
**[[5uh9]], [[5uh8]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA <br />
 +
**[[5uhg]], [[5uhc]], [[5uh6]], [[5uh5]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA + antibiotic<br />
 +
**[[5uhd]], [[5uhb]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + antibiotic<br />
 +
**[[5uhf]], [[5uhe]] - MtuRNAP subunits α,β,β’,ω + σ factor + DNA + RNA + inhibitor<br />
 +
 
 +
**[[3ihq]], [[1z3e]], [[3gfk]] - BsRNAP subunit α + regulatory protein SPX
**[[1l9u]] - TaRNAP subunits α,β,β’,ω + σ factor<br />
**[[1l9u]] - TaRNAP subunits α,β,β’,ω + σ factor<br />
**[[1l9z]] - TaRNAP subunits α,β,β’,ω + σ factor + DNA<br />
**[[1l9z]] - TaRNAP subunits α,β,β’,ω + σ factor + DNA<br />
-
**[[2jzb]] – RNAP subunit α + NUSA transcription elongation factor – ''Yersinia pseudotuberculosis''<br />
+
**[[2jzb]] – RNAP subunit α + NusA transcription elongation factor – ''Yersinia pseudotuberculosis''<br />
**[[3tbi]] - RNAP subunit β + GP33 – Enterobacteria phage T4<br />
**[[3tbi]] - RNAP subunit β + GP33 – Enterobacteria phage T4<br />
**[[3lpe ]]- MjRNAP subunit ε’’ + transcription antitermination protein<br />
**[[3lpe ]]- MjRNAP subunit ε’’ + transcription antitermination protein<br />
Line 133: Line 155:
**[[5g5l]], [[5lmx]], [[5m3f]], [[5m3m]], [[5m5w]], [[5m5x]], [[5m5y]], [[5m64]] – yRNAP I – Cryo EM<br />
**[[5g5l]], [[5lmx]], [[5m3f]], [[5m3m]], [[5m5w]], [[5m5x]], [[5m5y]], [[5m64]] – yRNAP I – Cryo EM<br />
**[[5n5y]], [[5n5z]], [[5n60]], [[5oa1]] – yRNAP I + RRN – Cryo EM<br />
**[[5n5y]], [[5n5z]], [[5n60]], [[5oa1]] – yRNAP I + RRN – Cryo EM<br />
-
**[[5n61]] – yRNAP I + RRN + DNA + RNA – Cryo EM<br />
+
**[[5n61]], [[6h68]], [[6h67]] – yRNAP I + RRN + DNA + RNA – Cryo EM<br />
 +
**[[5w66]], [[5w65]], [[5w64]], [[5w5y]] – yRNAP I + transcription initiation factor + DNA + RNA – Cryo EM<br />
*Eukaryotic DNA-dependent RNAP II
*Eukaryotic DNA-dependent RNAP II
Line 143: Line 166:
**[[2q5e]], [[3l0b]], [[3l0c]] - hRNAP II C terminal<br />
**[[2q5e]], [[3l0b]], [[3l0c]] - hRNAP II C terminal<br />
**[[1nik]], [[1nt9]], [[1wcm]], [[2b8k]], [[3fki]], [[3qt1]], [[1i3q]], [[1i50]], [[1dzf]], [[5ip7]], [[5ip9]], [[5u5q]] – yRNAP II<br />
**[[1nik]], [[1nt9]], [[1wcm]], [[2b8k]], [[3fki]], [[3qt1]], [[1i3q]], [[1i50]], [[1dzf]], [[5ip7]], [[5ip9]], [[5u5q]] – yRNAP II<br />
-
**[[4x67]], [[4x6a]], [[4y52]], [[4y7n]], [[5c3e]], [[5c44]], [[5c4a]], [[5c4j]], [[5c4x]] – yRNAP II + DNA + RNA<br />
+
**[[4x67]], [[4x6a]], [[4y52]], [[4y7n]], [[5c3e]], [[5c44]], [[5c4a]], [[5c4j]], [[5c4x]], [[6bqf]], [[6bm4]], [[6bm2]], [[6blp]], [[6blo]], [[5w51]], [[5w4u]] – yRNAP II + DNA + RNA<br />
-
**[[3j1n]], [[4v1n]], [[5fmf]] – yRNAP II – Cryo EM<br />
+
**[[6a5v]], [[6a5u]], [[6a5t]], [[6a5r]], [[6a5p]], [[6a5o]], [[6a6l]] – yRNAP II + DNA + RNA + histones – Cryo EM<br />
 +
**[[3j1n]], [[4v1n]], [[5fmf]], [[5x51]], [[5x50]], [[5x4z]] – yRNAP II – Cryo EM<br />
**[[1y14]] - yRNAP II subunits RPB4 RPB7<br />
**[[1y14]] - yRNAP II subunits RPB4 RPB7<br />
**[[5flm]] – bRNAP II + DNA + RNA - bovine<br />
**[[5flm]] – bRNAP II + DNA + RNA - bovine<br />
Line 159: Line 183:
**[[2dk5]] – hRNAP III winged helix domain (mutant) – NMR<br />
**[[2dk5]] – hRNAP III winged helix domain (mutant) – NMR<br />
**[[2yu3]] - hRNAP III winged helix domain<br />
**[[2yu3]] - hRNAP III winged helix domain<br />
-
**[[2ckz]], [[5fj9]], [[5fja]] - yRNAP III<br />
+
**[[2ckz]], [[5fj9]], [[5fja]], [[6eu3]], [[6eu2]] - yRNAP III - Cryo EM<br />
-
**[[5fj8]]- yRNAP III + DNA + RNA<br />
+
**[[5fj8]], [[6f41]] - yRNAP III + DNA + RNA - Cryo EM<br />
 +
**[[6f44]], [[6f42]], [[6f40]], [[6eu1]] - yRNAP III + DNA – Cryo EM<br />
 +
**[[6cnf]], [[6cnd]], [[6cnc]], [[6cnb]] - yRNAP III + DNA + TFIIIB – Cryo EM<br />
 +
**[[5xon]] - yRNAP III + DNA + RNA + TFIIB + SPT4 + SPT5 – Cryo EM<br />
 +
**[[5xog]] - yRNAP III + DNA + RNA + SPT5 + KOW5 + ELF1 – Cryo EM<br />
 +
**[[6eu0]] - yRNAP III + DNA + TFIIIB + TATA-box-binding protein – Cryo EM<br />
**[[3ayh]] - fyRNAP III subunit Rpc8+Rpc9<br />
**[[3ayh]] - fyRNAP III subunit Rpc8+Rpc9<br />
Line 167: Line 196:
**[[4lzd]] – hRNAP μ<br />
**[[4lzd]] – hRNAP μ<br />
**[[4lzg]], [[4m04]], [[4m0a]], [[5twp]], [[5twq]], [[5twr]], [[5tws]]. [[5txx]], [[5txz]], [[5tyb]], [[5tyc]], [[5tyd]], [[5tye]], [[5tyf]], [[5tyg]], [[5tyu]], [[5tyv]], [[5tyw]], [[5tyx]], [[5tyy]], [[5tyz]] – hRNAP μ + DNA<br />
**[[4lzg]], [[4m04]], [[4m0a]], [[5twp]], [[5twq]], [[5twr]], [[5tws]]. [[5txx]], [[5txz]], [[5tyb]], [[5tyc]], [[5tyd]], [[5tye]], [[5tyf]], [[5tyg]], [[5tyu]], [[5tyv]], [[5tyw]], [[5tyx]], [[5tyy]], [[5tyz]] – hRNAP μ + DNA<br />
 +
**[[5vzi]], [[5vzh]], [[5vzg]], [[5vzf]], [[5vze]], [[5vzd]], [[5vzc]], [[5vzb]], [[5vza]], [[5vz9]], [[5vz8]], [[5vz7]] – hRNAP μ (mutant) + DNA + nucleotide<br />
*Eukaryotic DNA-dependent RNAP mitochondrial
*Eukaryotic DNA-dependent RNAP mitochondrial
**[[4boc]] – hRNAP + DNA<br />
**[[4boc]] – hRNAP + DNA<br />
 +
**[[6erq]], [[6erp]] – hRNAP + DNA + MTTFA + dimethyladenosine transferase<br />
**[[3spa]] - hRNAP + polypeptide <br />
**[[3spa]] - hRNAP + polypeptide <br />
Line 184: Line 215:
**[[2yu9]], [[3i4m]], [[3i4n]] - yRNAP II + nucleotide + DNA + RNA<br />
**[[2yu9]], [[3i4m]], [[3i4n]] - yRNAP II + nucleotide + DNA + RNA<br />
**[[2vum]] - yRNAP II + inhibitor + DNA + RNA<br />
**[[2vum]] - yRNAP II + inhibitor + DNA + RNA<br />
 +
**[[5vvs]] - yRNAP II + DNA + RNA – Cryo EM<br />
*''Eukaryotic DNA-dependent RNAP II complex with protein''
*''Eukaryotic DNA-dependent RNAP II complex with protein''
Line 196: Line 228:
**[[2l0i]] – yRNAP C-terminal + RTT103 – NMR<br />
**[[2l0i]] – yRNAP C-terminal + RTT103 – NMR<br />
**[[4bxx]], [[4bxz]], [[4by1]], [[4by7]] – yRNAP II + RNA + DNA + transcription factor Bye1<br />
**[[4bxx]], [[4bxz]], [[4by1]], [[4by7]] – yRNAP II + RNA + DNA + transcription factor Bye1<br />
 +
**[[5vvr]] - yRNAP II + DNA + RNA + Rad26 – Cryo EM<br />
 +
**[[6gml]] – pRNAP II + RNA + DNA + DSIF + NELF – pig – Cryo EM<br />
 +
**[[6gmh]] – pRNAP II + RNA + DNA + DSIF + PAF + SPT6 – Cryo EM<br />
 +
**[[6exv]] – pRNAP II + RNA + DNA + amatoxin – Cryo EM<br />
*''Eukaryotic DNA-dependent RNAP complex with small molecule''
*''Eukaryotic DNA-dependent RNAP complex with small molecule''
Line 249: Line 285:
**[[3phu]], [[1khv]], [[1khw]] – HfRNAP L RNA-directed – Hemorrhagic fever virus<br />
**[[3phu]], [[1khv]], [[1khw]] – HfRNAP L RNA-directed – Hemorrhagic fever virus<br />
 +
**[[5v5i]], [[5v5h]], [[5v5g]] – HfRNAP L + ubiquitin<br />
**[[2xwh]], [[2xxd]], [[2xhu]],[[ 2xhw]], [[3i5k]], [[1c2p]], [[1csj]], [[1quv]], [[1yuy]], [[1yv2]], [[1yvx]], [[1yvz]], [[3gsz]], [[4aep]], [[4aex]], [[2wrm]], [[3mwv]], [[3mww]] – HvRNAP Ns5b domain – Hepatitis virus<br />
**[[2xwh]], [[2xxd]], [[2xhu]],[[ 2xhw]], [[3i5k]], [[1c2p]], [[1csj]], [[1quv]], [[1yuy]], [[1yv2]], [[1yvx]], [[1yvz]], [[3gsz]], [[4aep]], [[4aex]], [[2wrm]], [[3mwv]], [[3mww]] – HvRNAP Ns5b domain – Hepatitis virus<br />
**[[3vc8]] - HvRNAP cytoplasmic domain C terminal<br />
**[[3vc8]] - HvRNAP cytoplasmic domain C terminal<br />
Line 259: Line 296:
**[[2wk4]], [[2uut]], [[2uuw]] – SvRNAP (mutant) – Sapporo virus<br />
**[[2wk4]], [[2uut]], [[2uuw]] – SvRNAP (mutant) – Sapporo virus<br />
**[[2ckw]] - SvRNAP residues 1135-1649 <br />
**[[2ckw]] - SvRNAP residues 1135-1649 <br />
-
**[[3nky]], [[4wyl]], [[4wyw]] - FmRNAP (mutant) - Foot-and-mouth virus<br />
+
**[[3nky]], [[4wyl]], [[4wyw]], [[6gvv]] - FmRNAP (mutant) - Foot-and-mouth virus<br />
**[[1hhs]], [[4a8o]], [[4b02]], [[1hi8]], [[5fj6]] – P6RNAP – Bacteriophage φ-6<br />
**[[1hhs]], [[4a8o]], [[4b02]], [[1hi8]], [[5fj6]] – P6RNAP – Bacteriophage φ-6<br />
**[[2jl9]], [[2jlf]], [[1wac]] – P6RNAP (mutant) <br />
**[[2jl9]], [[2jlf]], [[1wac]] – P6RNAP (mutant) <br />
Line 325: Line 362:
**[[3phw]], [[2pt2]], [[3pt2]] – HfRNAP + ubiquitin<br />
**[[3phw]], [[2pt2]], [[3pt2]] – HfRNAP + ubiquitin<br />
**[[3phx]], [[3pse]] – HfRNAP + ISG15<br />
**[[3phx]], [[3pse]] – HfRNAP + ISG15<br />
-
**[[2d7s]], [[2f8e]] – FmRNAP + VPG protein<br />
+
**[[2d7s]], [[2f8e]] – FmRNAP + VPG <br />
 +
**[[5y3d]] – MnvRNAP + VPG <br />
**[[3cdw]] - CvRNAP + POP + VPG<br />
**[[3cdw]] - CvRNAP + POP + VPG<br />
**[[4f5x]] – SrRNAP + Vp2 + Vp6<br />
**[[4f5x]] – SrRNAP + Vp2 + Vp6<br />
Line 358: Line 396:
**[[3hw3]], [[3hw4]], [[3hw5]] - IvRNAP PA (mutant) + Mn + nucleotide – Influenza virus<br />
**[[3hw3]], [[3hw4]], [[3hw5]] - IvRNAP PA (mutant) + Mn + nucleotide – Influenza virus<br />
-
**[[3hw6]] - IvRNAP PA (mutant) + Mn<br />
+
**[[3hw6]], [[6fsb]] - IvRNAP PA (mutant) + Mn<br />
**[[3wi0]] – IvRNAP PA (mutant)<br />
**[[3wi0]] – IvRNAP PA (mutant)<br />
-
**[[4w9s]], [[5fdd]], [[5fdg]], [[5i13]], [[5ieq]], [[5if2]], [[5if5]], [[5if7]], [[5if8]], [[5ifb]], [[5ifc]], [[5ifd]] – IvRNAP PA + inhibitor<br />
+
**[[4w9s]], [[5fdd]], [[5fdg]], [[5i13]], [[5ieq]], [[5if2]], [[5if5]], [[5if7]], [[5if8]], [[5ifb]], [[5ifc]], [[5ifd]], [[5wa6]], [[5wa7]], [[5wb3]], [[5wap]], [[5w9g]], [[5w92]], [[5w44]], [[5v0u]] – IvRNAP PA + inhibitor<br />
 +
**[[5wg9]], [[5wfz]], [[5wfw]], [[5wfm]], [[5wf3]], [[5wei]], [[5wef]], [[5web]], [[5we9]], [[5we7]], [[5wdw]], [[5wdn]], [[5wdc]], [[5wct]], [[5wcs]], [[5w73]], [[5w7u]], [[5w3i]], [[5vrj]], [[5vqn]], [[5vpx]], [[5vpt]], [[5vp8]] – IvRNAP PA (mutant) + inhibitor<br />
**[[3cm8]] – IvRNAP PA + RNA-directed RNA polymerase PA peptide<br />
**[[3cm8]] – IvRNAP PA + RNA-directed RNA polymerase PA peptide<br />
**[[4wrt]], [[4wsa]] – IvRNAP PA + PB2 + RNA-directed RNA polymerase PA + RNA<br />
**[[4wrt]], [[4wsa]] – IvRNAP PA + PB2 + RNA-directed RNA polymerase PA + RNA<br />
**[[4e5e]], [[4zqq]], [[5jht]], [[5jhv]] – IvRNAP PA residues 1-50, 73-196 + Mn<br />
**[[4e5e]], [[4zqq]], [[5jht]], [[5jhv]] – IvRNAP PA residues 1-50, 73-196 + Mn<br />
-
**[[4e5f]], [[4e5g]], [[4e5h]], [[4e5i]], [[4e5j]], [[4e5l]], [[4yyl]], [[4zhz]], [[4zi0]] – IvRNAP PA residues 1-50, 73-196 + Mn + inhibitor<br />
+
**[[4e5f]], [[4e5g]], [[4e5h]], [[4e5i]], [[4e5j]], [[4e5l]], [[4yyl]], [[4zhz]], [[4zi0]], [[6fs7]], [[6fs6]] – IvRNAP PA residues 1-50, 73-196 + Mn + inhibitor<br />
 +
**[[6fs8]] – IvRNAP PA residues 1-196 + Mn + inhibitor<br />
 +
**[[6fs9]] – IvRNAP PA residues 1-196 (mutant) + Mn + inhibitor<br />
**[[3ebj]], [[2w69]] - IvRNAP PA residues 1-256<br />
**[[3ebj]], [[2w69]] - IvRNAP PA residues 1-256<br />
**[[4iuj]] - IvRNAP PA residues 254-713<br />
**[[4iuj]] - IvRNAP PA residues 254-713<br />
-
*Influenza virus polymerase basic protein 2 (or RNAP subunit P3 or PB2)
+
*Influenza virus polymerase basic protein 2 (or RNAP subunit P3 or PB2)); Domains: cap-binding 318-483; Cap-binding and midlink 247-536; 627 538-693; NLS 694-753
**[[4enf]], [[4u6o]], [[4j2r]], [[2vqz]], [[5ef9]], [[5eg9]] – IvRNAP PB2 cap-binding domain<br />
**[[4enf]], [[4u6o]], [[4j2r]], [[2vqz]], [[5ef9]], [[5eg9]] – IvRNAP PB2 cap-binding domain<br />
-
**[[4j2r]] – IvRNAP PB2 middle domain<br />
+
**[[3cw4]] - IvRNAP PB2 627 + NLS domains <br />
-
**[[3cw4]] - IvRNAP PB2 C terminal <br />
+
**[[2gmo]] - IvRNAP PB2 627 + NLS domains - NMR<br />
-
**[[2gmo]] - IvRNAP PB2 C terminal - NMR<br />
+
**[[4eqk]], [[5efa]], [[5efc]] – IvRNAP PB2 cap-binding domain + nucleotide<br />
**[[4eqk]], [[5efa]], [[5efc]] – IvRNAP PB2 cap-binding domain + nucleotide<br />
**[[4nce]], [[3wi1]] – IvRNAP PB2 cap-binding domain (mutant) + nucleotide<br />
**[[4nce]], [[3wi1]] – IvRNAP PB2 cap-binding domain (mutant) + nucleotide<br />
**[[4ncm]] – IvRNAP PB2 cap-binding domain (mutant) + inhibitor<br />
**[[4ncm]] – IvRNAP PB2 cap-binding domain (mutant) + inhibitor<br />
**[[4p1u]], [[4yd0]], [[5buh]], [[5jun]], [[5jur]] - IvRNAP PB2 cap-binding domain + inhibitor<br />
**[[4p1u]], [[4yd0]], [[5buh]], [[5jun]], [[5jur]] - IvRNAP PB2 cap-binding domain + inhibitor<br />
 +
**[[6euy]], [[6eux]], [[6euv]] - IvRNAP PB2 cap-binding + midlink domains + inhibitor<br />
 +
**[[5wl0]] - IvRNAP PB2 cap-binding + midlink + 627 + NLS domains + inhibitor<br />
**[[4uad]], [[4uae]], [[4uaf]] - IvRNAP PB2 + importin<br />
**[[4uad]], [[4uae]], [[4uaf]] - IvRNAP PB2 + importin<br />
**[[2vy6]] - IvRNAP PB2 627- and NLS domains<br />
**[[2vy6]] - IvRNAP PB2 627- and NLS domains<br />
Line 392: Line 434:
**[[3j9b]] - IvRNAP PB1+PB2 + RNA<br />
**[[3j9b]] - IvRNAP PB1+PB2 + RNA<br />
-
*Influenza virus pRNAP PA+PB1+PB2
+
*Influenza virus RNAP PA+PB1+PB2
-
**[[4wsb]], [[5fmz]], [[5m3h]], [[5m3j]], [[5msg]] - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA<br />
+
**[[4wsb]], [[5fmz]], [[5m3h]], [[5m3j]], [[5msg]], [[6f5o]], [[6evj]] - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA<br />
 +
**[[6evk]] - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + RNA + GTP<br />
**[[5d98]], [[5d9a]] - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2<br />
**[[5d98]], [[5d9a]] - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2<br />
 +
**[[6f5p]] - IvRNAP PB1 + IvRNAP PA + IvRNAP PB2 + polyAla<br />
*Poly(A) RNA polymerase
*Poly(A) RNA polymerase

Revision as of 08:58, 18 October 2018

Yeast RNA polymerase II elongation complex C complexed with DNA and RNA and Zn+2 (grey) and Mg+2 (green) ions 3m3y. Subunit B1 (grey), B2 (green), B3 (pink), B9 (wheat), B11 (rust), ABC1 (magenta), ABC2 (cyan), ABC3 (red), ABC4 (aqua), ABC5 (blue) (PDB code 3m3y).

Drag the structure with the mouse to rotate

3D Structures of RNA polymerase

Updated on 18-October-2018

References

  1. ↑ Cramer P, Armache KJ, Baumli S, Benkert S, Brueckner F, Buchen C, Damsma GE, Dengl S, Geiger SR, Jasiak AJ, Jawhari A, Jennebach S, Kamenski T, Kettenberger H, Kuhn CD, Lehmann E, Leike K, Sydow JF, Vannini A. Structure of eukaryotic RNA polymerases. Annu Rev Biophys. 2008;37:337-52. doi: 10.1146/annurev.biophys.37.032807.130008. PMID:18573085 doi:http://dx.doi.org/10.1146/annurev.biophys.37.032807.130008
  2. ↑ Comai L. Mechanism of RNA polymerase I transcription. Adv Protein Chem. 2004;67:123-55. PMID:14969726 doi:http://dx.doi.org/10.1016/S0065-3233(04)67005-7
  3. ↑ Hahn S. Structure and mechanism of the RNA polymerase II transcription machinery. Nat Struct Mol Biol. 2004 May;11(5):394-403. PMID:15114340 doi:http://dx.doi.org/10.1038/nsmb763
  4. ↑ Longo DL, Herbert V. Radioassay for serum and red cell folate. J Lab Clin Med. 1976 Jan;87(1):138-51. PMID:1452
  5. ↑ Frick DN, Richardson CC. DNA primases. Annu Rev Biochem. 2001;70:39-80. PMID:11395402 doi:http://dx.doi.org/10.1146/annurev.biochem.70.1.39
  6. ↑ Naue N, Beerbaum M, Bogutzki A, Schmieder P, Curth U. The helicase-binding domain of Escherichia coli DnaG primase interacts with the highly conserved C-terminal region of single-stranded DNA-binding protein. Nucleic Acids Res. 2013 Apr;41(8):4507-17. doi: 10.1093/nar/gkt107. Epub 2013 Feb, 20. PMID:23430154 doi:http://dx.doi.org/10.1093/nar/gkt107
  7. ↑ Ahlquist P. RNA-dependent RNA polymerases, viruses, and RNA silencing. Science. 2002 May 17;296(5571):1270-3. PMID:12016304 doi:http://dx.doi.org/10.1126/science.1069132
  8. ↑ Fukushi S, Kojima S, Takai R, Hoshino FB, Oka T, Takeda N, Katayama K, Kageyama T. Poly(A)- and primer-independent RNA polymerase of Norovirus. J Virol. 2004 Apr;78(8):3889-96. PMID:15047805

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