2rli
From Proteopedia
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|PDB= 2rli |SIZE=350|CAPTION= <scene name='initialview01'>2rli</scene> | |PDB= 2rli |SIZE=350|CAPTION= <scene name='initialview01'>2rli</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CU1:COPPER (I) ION'>CU1</scene> | + | |LIGAND= <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= SCO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= SCO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rli OCA], [http://www.ebi.ac.uk/pdbsum/2rli PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rli RCSB]</span> | ||
}} | }} | ||
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[[Category: SPINE, Structural Proteomics in Europe.]] | [[Category: SPINE, Structural Proteomics in Europe.]] | ||
[[Category: Wang, S.]] | [[Category: Wang, S.]] | ||
| - | [[Category: CU1]] | ||
[[Category: copper protein]] | [[Category: copper protein]] | ||
[[Category: metal transport]] | [[Category: metal transport]] | ||
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[[Category: thioredoxin fold]] | [[Category: thioredoxin fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:01:44 2008'' |
Revision as of 02:01, 31 March 2008
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| Ligands: | |||||||
| Gene: | SCO2 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of Cu(I) human Sco2
Contents |
Overview
Human Sco2 is a mitochondrial membrane-bound protein involved in copper supply for the assembly of cytochrome c oxidase in eukaryotes. Its precise action is not yet understood. We report here a structural and dynamic characterization by NMR of the apo and copper(I) forms of the soluble fragment. The structural and metal binding features of human Cu(I)Sco2 are similar to the more often studied Sco1 homolog, although the dynamic properties and the conformational disorder are quite different when the apo forms and the copper(I)-loaded forms of the two proteins are compared separately. Such differences are accounted for in terms of the different physicochemical properties in strategic protein locations. The misfunction of the known pathogenic mutations is discussed on the basis of the obtained structure.
Disease
Known disease associated with this structure: Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency OMIM:[604272]
About this Structure
2RLI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A structural characterization of human SCO2., Banci L, Bertini I, Ciofi-Baffoni S, Gerothanassis IP, Leontari I, Martinelli M, Wang S, Structure. 2007 Sep;15(9):1132-40. PMID:17850752
Page seeded by OCA on Mon Mar 31 05:01:44 2008
Categories: Homo sapiens | Single protein | Banci, L. | Bertini, I. | Ciofi-baffoni, S. | Gerothanassis, I P. | Leontari, I. | Martinelli, M. | SPINE, Structural Proteomics in Europe. | Wang, S. | Copper protein | Metal transport | Spine | Spine2-complex | Structural genomic | Structural proteomics in europe | Thioredoxin fold
