6ded
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the C-terminal ARM domain of Homo sapiens SPIN90 (SH3-protein interacting with Nck), residues 351-722== | |
| - | + | <StructureSection load='6ded' size='340' side='right' caption='[[6ded]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ded]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DED FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ded FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ded OCA], [http://pdbe.org/6ded PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ded RCSB], [http://www.ebi.ac.uk/pdbsum/6ded PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ded ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/SPN90_HUMAN SPN90_HUMAN]] A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with KMT2A/MLL1.<ref>PMID:10648423</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPN90_HUMAN SPN90_HUMAN]] Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.<ref>PMID:22419821</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Luan, Q]] | [[Category: Luan, Q]] | ||
| + | [[Category: Nolen, B J]] | ||
| + | [[Category: And 2-3 armadillo repeat]] | ||
| + | [[Category: Endocytosis]] | ||
| + | [[Category: Inactive form]] | ||
| + | [[Category: N-terminally truncated spin90]] | ||
| + | [[Category: Unable to activate arp2-3 complex]] | ||
Revision as of 05:53, 24 October 2018
Crystal structure of the C-terminal ARM domain of Homo sapiens SPIN90 (SH3-protein interacting with Nck), residues 351-722
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