6ew8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand== | |
| - | + | <StructureSection load='6ew8' size='340' side='right' caption='[[6ew8]], [[Resolution|resolution]] 1.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ew8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EW8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C0Q:anilinopyrimidine+ligand'>C0Q</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5n21|5n21]], [[5n20|5n20]], [[5n1z|5n1z]], [[5n1x|5n1x]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ew8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ew8 OCA], [http://pdbe.org/6ew8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ew8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ew8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ew8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ferguson, A]] | ||
| + | [[Category: Hargreaves, D]] | ||
[[Category: Robb, G]] | [[Category: Robb, G]] | ||
| - | [[Category: | + | [[Category: Kinase]] |
| - | [[Category: | + | [[Category: Transferase]] |
Revision as of 05:55, 24 October 2018
Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand
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