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6hcy
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==human STEAP4 bound to NADP, FAD, heme and Fe(III)-NTA.== | |
| - | + | <StructureSection load='6hcy' size='340' side='right' caption='[[6hcy]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hcy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44E:(2R)-3-(PHOSPHONOOXY)PROPANE-1,2-DIYL+DIHEXANOATE'>44E</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hcy OCA], [http://pdbe.org/6hcy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hcy RCSB], [http://www.ebi.ac.uk/pdbsum/6hcy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hcy ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/STEA4_HUMAN STEA4_HUMAN]] Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).<ref>PMID:18381574</ref> <ref>PMID:18430367</ref> <ref>PMID:19660107</ref> <ref>PMID:19787193</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bezouwen, L S.van]] | ||
| + | [[Category: Forster, F]] | ||
| + | [[Category: Gros, P]] | ||
| + | [[Category: Mattevi, A]] | ||
| + | [[Category: Oosterheert, W]] | ||
| + | [[Category: Rodenburg, R N.P]] | ||
| + | [[Category: Cofactor-binding]] | ||
| + | [[Category: Electron transfer]] | ||
| + | [[Category: Enzyme]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Metalloreductase]] | ||
Revision as of 05:59, 24 October 2018
human STEAP4 bound to NADP, FAD, heme and Fe(III)-NTA.
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