6mlc

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m (Protected "6mlc" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6mlc is ON HOLD
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==PHD6 domain of MLL3 in complex with histone H4==
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<StructureSection load='6mlc' size='340' side='right' caption='[[6mlc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Dong, A., Liu, Y., Qin, S., Lei, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mlc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLC FirstGlance]. <br>
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Description: PHD6 domain of MLL3 in complex with histone H4
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlc OCA], [http://pdbe.org/6mlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlc RCSB], [http://www.ebi.ac.uk/pdbsum/6mlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KMT2C_HUMAN KMT2C_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Dong, A]]
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[[Category: Edwards, A M]]
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[[Category: Lei, M]]
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[[Category: Liu, Y]]
[[Category: Min, J]]
[[Category: Min, J]]
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[[Category: Edwards, A.M]]
 
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[[Category: Arrowsmith, C.H]]
 
[[Category: Qin, S]]
[[Category: Qin, S]]
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[[Category: Dong, A]]
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[[Category: Structural genomic]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Mll3]]
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[[Category: Liu, Y]]
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[[Category: Phd6]]
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[[Category: Lei, M]]
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[[Category: Sgc]]
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[[Category: Bountra, C]]
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[[Category: Transferase]]

Revision as of 06:06, 24 October 2018

PHD6 domain of MLL3 in complex with histone H4

6mlc, resolution 1.80Å

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OCA

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