6bqn
From Proteopedia
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<StructureSection load='6bqn' size='340' side='right' caption='[[6bqn]], [[Resolution|resolution]] 3.90Å' scene=''> | <StructureSection load='6bqn' size='340' side='right' caption='[[6bqn]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6bqn]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQN FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6bqn]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQN FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqn OCA], [http://pdbe.org/6bqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqn RCSB], [http://www.ebi.ac.uk/pdbsum/6bqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqn OCA], [http://pdbe.org/6bqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqn RCSB], [http://www.ebi.ac.uk/pdbsum/6bqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The epithelial sodium channel (ENaC), a member of the ENaC/DEG superfamily, regulates Na(+) and water homeostasis. ENaCs assemble as heterotrimeric channels that harbor protease-sensitive domains critical for gating the channel. Here, we present the structure of human ENaC in the uncleaved state determined by single-particle cryo-electron microscopy. The ion channel is composed of a large extracellular domain and a narrow transmembrane domain. The structure reveals that ENaC assembles with a 1:1:1 stoichiometry of alpha:beta:gamma subunits arranged in a counter-clockwise manner. The shape of each subunit is reminiscent of a hand with key gating domains of a 'finger' and a 'thumb.' Wedged between these domains is the elusive protease-sensitive inhibitory domain poised to regulate conformational changes of the 'finger' and 'thumb'; thus, the structure provides the first view of the architecture of inhibition of ENaC. | ||
| + | |||
| + | Structure of the human epithelial sodium channel by cryo-electron microscopy.,Noreng S, Bharadwaj A, Posert R, Yoshioka C, Baconguis I Elife. 2018 Sep 25;7. pii: 39340. doi: 10.7554/eLife.39340. PMID:30251954<ref>PMID:30251954</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6bqn" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Baconguis, I]] | [[Category: Baconguis, I]] | ||
Revision as of 06:43, 24 October 2018
Cryo-EM structure of ENaC
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