6crm
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='6crm' size='340' side='right' caption='[[6crm]], [[Resolution|resolution]] 2.19Å' scene=''> | <StructureSection load='6crm' size='340' side='right' caption='[[6crm]], [[Resolution|resolution]] 2.19Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6crm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CRM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6crm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cros8 Cros8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CRM FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESA_03738 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290339 CROS8])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6crm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6crm OCA], [http://pdbe.org/6crm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6crm RCSB], [http://www.ebi.ac.uk/pdbsum/6crm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6crm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6crm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6crm OCA], [http://pdbe.org/6crm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6crm RCSB], [http://www.ebi.ac.uk/pdbsum/6crm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6crm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Homeostatic regulation of G-quadruplexes (G4s), four-stranded structures that can form in guanine-rich nucleic acids, requires G4 unwinding helicases. The mechanisms that mediate G4 unwinding remain unknown. We report the structure of a bacterial RecQ DNA helicase bound to resolved G4 DNA. Unexpectedly, a guanine base from the unwound G4 is sequestered within a guanine-specific binding pocket. Disruption of the pocket in RecQ blocks G4 unwinding, but not G4 binding or duplex DNA unwinding, indicating its essential role in structure-specific G4 resolution. A novel guanine-flipping and sequestration model that may be applicable to other G4-resolving helicases emerges from these studies. | ||
| + | |||
| + | A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases.,Voter AF, Qiu Y, Tippana R, Myong S, Keck JL Nat Commun. 2018 Oct 10;9(1):4201. doi: 10.1038/s41467-018-06751-8. PMID:30305632<ref>PMID:30305632</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6crm" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Cros8]] | ||
[[Category: Keck, J L]] | [[Category: Keck, J L]] | ||
[[Category: Voter, A F]] | [[Category: Voter, A F]] | ||
Revision as of 06:46, 24 October 2018
Crystal Structure of RecQ catalytic core from C. sakazakii bound to an unfolded G-quadruplex
| |||||||||||
