3a98
From Proteopedia
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/DOCK2_HUMAN DOCK2_HUMAN]] Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.<ref>PMID:21613211</ref> [[http://www.uniprot.org/uniprot/ELMO1_HUMAN ELMO1_HUMAN]] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.<ref>PMID:11595183</ref> <ref>PMID:12134158</ref> | [[http://www.uniprot.org/uniprot/DOCK2_HUMAN DOCK2_HUMAN]] Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.<ref>PMID:21613211</ref> [[http://www.uniprot.org/uniprot/ELMO1_HUMAN ELMO1_HUMAN]] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.<ref>PMID:11595183</ref> <ref>PMID:12134158</ref> | ||
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| + | ==See Also== | ||
| + | *[[Dedicator of cytokinesis protein|Dedicator of cytokinesis protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 07:35, 24 October 2018
Crystal structure of the complex of the interacting regions of DOCK2 and ELMO1
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Categories: Human | Fukui, Y | Hanawa-Suetsugu, K | Ito, T | Kukimoto-Niino, M | Mishima-Tsumagari, C | Sekine, S | Shirouzu, M | Terada, T | Yokoyama, S | Apoptosis | Cell membrane | Cytoskeleton | Dock2 | Elmo1 | Guanine-nucleotide releasing factor | Helix bundle | Membrane | Ph domain | Phagocytosis | Phosphoprotein | Proline-rich sequence | Protein-protein complex | Sh3 domain | Sh3-binding | Signaling protein
