Gephyrin

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<StructureSection load='4u91' size='340' side='right' caption='Rat gephyrin E domain (grey) complex with glycine receptor peptide (green), acetate and Ca+2 ion (green) (PDB code [[4u91]])' scene='80/800120/Cv/1'>
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<StructureSection load='4u91' size='340' side='right' caption='Rat gephyrin E domain (grey) complex with glycine receptor peptide (magenta), acetate and Ca+2 ion (green) (PDB code [[4u91]])' scene='80/800120/Cv/2'>
== Function ==
== Function ==

Revision as of 10:49, 29 October 2018

Rat gephyrin E domain (grey) complex with glycine receptor peptide (magenta), acetate and Ca+2 ion (green) (PDB code 4u91)

Drag the structure with the mouse to rotate

3D structures of gephyrin

Updated on 29-October-2018

2fu3, 5erq, 4pd0 - rGeph E domain 318-736 - rat
2fts, 4pd1, 1t3e, 4u91 - rGeph E domain + glycine receptor peptide
4tk1, 4tk2, 4tk3, 4tk4, 4u90 - rGeph E domain + GABA receptor peptide
5ers - rGeph E domain + AMP
5ert, 5err - rGeph E domain + ADP
5eru - rGeph E domain + ADP + Mo + MoO4
5erv - rGeph E domain + ADP + W + WO4
1thc - rGeph N terminal

References

  1. ↑ Tyagarajan SK, Fritschy JM. Gephyrin: a master regulator of neuronal function? Nat Rev Neurosci. 2014 Mar;15(3):141-56. doi: 10.1038/nrn3670. PMID:24552784 doi:http://dx.doi.org/10.1038/nrn3670
  2. ↑ Hales CM, Rees H, Seyfried NT, Dammer EB, Duong DM, Gearing M, Montine TJ, Troncoso JC, Thambisetty M, Levey AI, Lah JJ, Wingo TS. Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes. J Neuropathol Exp Neurol. 2013 Nov;72(11):1009-15. doi:, 10.1097/01.jnen.0000435847.59828.db. PMID:24128675 doi:http://dx.doi.org/10.1097/01.jnen.0000435847.59828.db
  3. ↑ Maric HM, Kasaragod VB, Haugaard-Kedstrom L, Hausrat TJ, Kneussel M, Schindelin H, Stromgaard K. Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors. Angew Chem Int Ed Engl. 2014 Nov 20. doi: 10.1002/anie.201409043. PMID:25413248 doi:http://dx.doi.org/10.1002/anie.201409043

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Alexander Berchansky, Michal Harel

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