2uuv
From Proteopedia
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|PDB= 2uuv |SIZE=350|CAPTION= <scene name='initialview01'>2uuv</scene>, resolution 1.99Å | |PDB= 2uuv |SIZE=350|CAPTION= <scene name='initialview01'>2uuv</scene>, resolution 1.99Å | ||
|SITE= <scene name='pdbsite=AC1:Pl3+Binding+Site+For+Chain+D'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Pl3+Binding+Site+For+Chain+D'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene> | + | |LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PL3:HEXADECAN-1-OL'>PL3</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Alkylglycerone-phosphate_synthase Alkylglycerone-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.26 2.5.1.26] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerone-phosphate_synthase Alkylglycerone-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.26 2.5.1.26] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uuv OCA], [http://www.ebi.ac.uk/pdbsum/2uuv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uuv RCSB]</span> | ||
}} | }} | ||
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[[Category: Pandini, V.]] | [[Category: Pandini, V.]] | ||
[[Category: Razeto, A.]] | [[Category: Razeto, A.]] | ||
| - | [[Category: FAD]] | ||
| - | [[Category: PL3]] | ||
[[Category: biosynthesis of phospholipid]] | [[Category: biosynthesis of phospholipid]] | ||
[[Category: fad]] | [[Category: fad]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:04:49 2008'' |
Revision as of 02:04, 31 March 2008
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| , resolution 1.99Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , | ||||||
| Activity: | Alkylglycerone-phosphate synthase, with EC number 2.5.1.26 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE IN P1
Overview
Ether phospholipids are essential constituents of eukaryotic cell membranes. Rhizomelic chondrodysplasia punctata type 3 is a severe peroxisomal disorder caused by inborn deficiency of alkyldihydroxyacetonephosphate synthase (ADPS). The enzyme carries out the most characteristic step in ether phospholipid biosynthesis: formation of the ether bond. The crystal structure of ADPS from Dictyostelium discoideum shows a fatty-alcohol molecule bound in a narrow hydrophobic tunnel, specific for aliphatic chains of 16 carbons. Access to the tunnel is controlled by a flexible loop and a gating helix at the protein-membrane interface. Structural and mutagenesis investigations identify a cluster of hydrophilic catalytic residues, including an essential tyrosine, possibly involved in substrate proton abstraction, and the arginine that is mutated in ADPS-deficient patients. We propose that ether bond formation might be orchestrated through a covalent imine intermediate with the flavin, accounting for the noncanonical employment of a flavin cofactor in a nonredox reaction.
About this Structure
2UUV is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.
Reference
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder., Razeto A, Mattiroli F, Carpanelli E, Aliverti A, Pandini V, Coda A, Mattevi A, Structure. 2007 Jun;15(6):683-92. PMID:17562315
Page seeded by OCA on Mon Mar 31 05:04:49 2008
Categories: Alkylglycerone-phosphate synthase | Dictyostelium discoideum | Single protein | Aliverti, A. | Carpanelli, E. | Coda, A. | Mattevi, A. | Mattiroli, F. | Pandini, V. | Razeto, A. | Biosynthesis of phospholipid | Fad | Flavin | Flavoprotein | Lipid synthesis | Peroxisomal disorder | Peroxisome | Plasmalogen | Rhizomelic chondrodysplasia punctata | Transferase
