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6e8a
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of DcrB from Salmonella enterica at 1.92 Angstroms resolution== | |
| + | <StructureSection load='6e8a' size='340' side='right' caption='[[6e8a]], [[Resolution|resolution]] 1.92Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6e8a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E8A FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e8a OCA], [http://pdbe.org/6e8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e8a RCSB], [http://www.ebi.ac.uk/pdbsum/6e8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e8a ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | DcrB is an 18kDa lipoprotein that contains a single domain of unknown function. DcrB is found within Enterobacteriaceae, a family of Gram-negative bacteria which includes pathogens that can cause food-borne illness and hospital-acquired infections. In Salmonella enterica serovar Typhimurium, DcrB is up-regulated by conditions that promote the production of known virulence factors. We determined the structure of a truncated form of DcrB from Salmonella to 1.92A resolution by X-ray crystallography. This truncated form, DcrBDelta37, contains the entire domain of unknown function but lacks the lipoprotein signal sequence (residues 1-20) as well as residues 21-37. The DcrBDelta37 monomer contains the Mog1p/PsbP-like fold, which is found in functionally diverse proteins in mammals, yeast, plants, and cyanobacteria. Interestingly, DcrBDelta37 crystallized as a domain-swapped homodimer in which the N-terminal beta-hairpin extends from one protomer to interact with the core of the second protomer. This domain-swapping indicates that the N-terminal portion of the Mog1p/PsbP-like fold likely has conformational flexibility. Overall, our results provide the first example of an enterobacterial protein that contains the Mog1p/PsbP-like fold and expands knowledge of the structural and phylogenetic diversity of Mog1p/PsbP-like proteins. | ||
| - | + | The structure of DcrB, a lipoprotein from Salmonella enterica, reveals flexibility in the N-terminal segment of the Mog1p/PsbP-like fold.,Rasmussen DM, Soens RW, Davie TJ, Vaneerd CK, Bhattacharyya B, May JF J Struct Biol. 2018 Oct 16. pii: S1047-8477(18)30278-8. doi:, 10.1016/j.jsb.2018.10.005. PMID:30339832<ref>PMID:30339832</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6e8a" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bhattacharyya, B]] | ||
| + | [[Category: May, J F]] | ||
| + | [[Category: Rasmussen, D M]] | ||
| + | [[Category: Soens, R W]] | ||
| + | [[Category: Mog1/psbp-like fold lipoprotein]] | ||
| + | [[Category: Unknown function]] | ||
Revision as of 06:51, 31 October 2018
Crystal structure of DcrB from Salmonella enterica at 1.92 Angstroms resolution
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