6eq3

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m (Protected "6eq3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6eq3 is ON HOLD until Paper Publication
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==MTH1 in complex with fragment 9==
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<StructureSection load='6eq3' size='340' side='right' caption='[[6eq3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Wiedmer, L., Sledz, P., Caflisch, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6eq3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQ3 FirstGlance]. <br>
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Description: MTH1 in complex with fragment 9
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BU5:[2-(1~{H}-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-4-yl]methanol'>BU5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eq3 OCA], [http://pdbe.org/6eq3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eq3 RCSB], [http://www.ebi.ac.uk/pdbsum/6eq3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eq3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caflisch, A]]
[[Category: Caflisch, A]]
[[Category: Sledz, P]]
[[Category: Sledz, P]]
[[Category: Wiedmer, L]]
[[Category: Wiedmer, L]]
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[[Category: Complex]]
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[[Category: Dna repair]]
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[[Category: Fragment]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]

Revision as of 06:53, 31 October 2018

MTH1 in complex with fragment 9

6eq3, resolution 1.80Å

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