6eq6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6eq6" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6eq6 is ON HOLD until Paper Publication
+
==MTH1 in complex with fragment 1==
-
 
+
<StructureSection load='6eq6' size='340' side='right' caption='[[6eq6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
Authors: Wiedmer, L., Sledz, P., Caflisch, A.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6eq6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQ6 FirstGlance]. <br>
-
Description: MTH1 in complex with fragment 1
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EV2:3-PYRROLIDIN-1-YLQUINOXALIN-2-AMINE'>EV2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eq6 OCA], [http://pdbe.org/6eq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eq6 RCSB], [http://www.ebi.ac.uk/pdbsum/6eq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eq6 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Caflisch, A]]
[[Category: Caflisch, A]]
[[Category: Sledz, P]]
[[Category: Sledz, P]]
[[Category: Wiedmer, L]]
[[Category: Wiedmer, L]]
 +
[[Category: Complex]]
 +
[[Category: Dna repair]]
 +
[[Category: Fragment]]
 +
[[Category: Hydrolase]]
 +
[[Category: Inhibitor]]

Revision as of 06:53, 31 October 2018

MTH1 in complex with fragment 1

6eq6, resolution 2.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6eq6"
Personal tools