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2uzg
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2uzg |SIZE=350|CAPTION= <scene name='initialview01'>2uzg</scene> | |PDB= 2uzg |SIZE=350|CAPTION= <scene name='initialview01'>2uzg</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uzg OCA], [http://www.ebi.ac.uk/pdbsum/2uzg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uzg RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Allen, M D.]] | [[Category: Allen, M D.]] | ||
[[Category: Bycroft, M.]] | [[Category: Bycroft, M.]] | ||
| - | [[Category: ZN]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: de-ubiquitination]] | [[Category: de-ubiquitination]] | ||
| Line 38: | Line 40: | ||
[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:36 2008'' |
Revision as of 02:06, 31 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
ZF-UBP DOMAIN OF VDU1
Overview
USP33/VDU1 is a deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein. It also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase. USP33/VDU1 contains a ZF UBP domain, a protein module found in many proteins in the ubiquitin-proteasome system. Several ZF UBP domains have been shown to bind ubiquitin, and a structure of a complex of the ZF UBP domain of isoT/USP5 and ubiquitin is available. In the present work, the solution structure of the ZF UBP domain of USP33/VDU1 has been determined by NMR spectroscopy. The structure differs from that of the USP5 domain, which contains only one of the three Zn ions present in the USP33/VDU1 structure. The USP33/VDU1 ZnF UBP domain does not bind to ubiquitin.
About this Structure
2UZG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The solution structure of the ZnF UBP domain of USP33/VDU1., Allen MD, Bycroft M, Protein Sci. 2007 Sep;16(9):2072-5. PMID:17766394
Page seeded by OCA on Mon Mar 31 05:06:36 2008
