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3b2r
From Proteopedia
(Difference between revisions)
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==Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil== | ==Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil== | ||
<StructureSection load='3b2r' size='340' side='right' caption='[[3b2r]], [[Resolution|resolution]] 2.07Å' scene=''> | <StructureSection load='3b2r' size='340' side='right' caption='[[3b2r]], [[Resolution|resolution]] 2.07Å' scene=''> | ||
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b2r OCA], [http://pdbe.org/3b2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b2r RCSB], [http://www.ebi.ac.uk/pdbsum/3b2r PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b2r OCA], [http://pdbe.org/3b2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b2r RCSB], [http://www.ebi.ac.uk/pdbsum/3b2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b2r ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/3b2r_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/3b2r_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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[[Category: Sharron, H F]] | [[Category: Sharron, H F]] | ||
[[Category: Allosteric enzyme]] | [[Category: Allosteric enzyme]] | ||
| + | [[Category: Alternative splicing]] | ||
[[Category: Cgmp phosphodiesterase]] | [[Category: Cgmp phosphodiesterase]] | ||
[[Category: Cgmp-binding]] | [[Category: Cgmp-binding]] | ||
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[[Category: Pde5-inhibitor potency]] | [[Category: Pde5-inhibitor potency]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
| + | [[Category: Polymorphism]] | ||
[[Category: Sildenafil]] | [[Category: Sildenafil]] | ||
[[Category: Vardenafil]] | [[Category: Vardenafil]] | ||
| + | [[Category: Zinc]] | ||
Revision as of 07:58, 31 October 2018
Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil
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Categories: 3',5'-cyclic-GMP phosphodiesterase | Homo sapiens | Hengming, K | Howard, R | Huanchen, W | Mengchun, Y | Sharron, H F | Allosteric enzyme | Alternative splicing | Cgmp phosphodiesterase | Cgmp-binding | Hydrolase | Levitratm | Magnesium | Metal-binding | Nucleotide-binding | Pde5-inhibitor potency | Phosphorylation | Polymorphism | Sildenafil | Vardenafil | Zinc
