DnaJ homolog

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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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<ref>PMID:21638687</ref> to the rescue.
 
== Function ==
== Function ==
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'''DnaJ homolog subfamily A member 1''' (DnaJA1) is a co-chaperone for HSPA8/Hsc70. DnaJ1 stimulates ATP synthesis and has a role in protein transport into mitochondria<ref>PMID:10816573</ref>.
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'''DnaJ homolog subfamily A member 1''' (DnaJA1) is a co-chaperone for HSPA8/Hsc70. DnaJA1 stimulates ATP synthesis and has a role in protein transport into mitochondria<ref>PMID:10816573</ref>.<br />
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'''DnaJ homolog subfamily B member 1''' (DnaJB1) interacts with HSP70. DnaJB1 stimulates ATP synthesis and the folding of unfolded proteins mediated by HSPA1A <ref>PMID:24318877</ref>.<br />
== Disease ==
== Disease ==
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*DnaJ homolog subfamily A member 1
*DnaJ homolog subfamily A member 1
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**[[2l01]], [[2m6y]] - hDnaJ J domain - human - NMR<br />
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**[[2l01]], [[2m6y]] - hDnaJA1 J domain - human - NMR<br />
*DnaJ homolog subfamily A member 3
*DnaJ homolog subfamily A member 3
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**[[2dn9]] - hDnaJ J domain - NMR<br />
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**[[2dn9]] - hDnaJA3 J domain - NMR<br />
**[[2ctt]] - hDnaJ zinc finger domain - NMR<br />
**[[2ctt]] - hDnaJ zinc finger domain - NMR<br />
*DnaJ homolog subfamily B member 1
*DnaJ homolog subfamily B member 1
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**[[3agx]], [[2qld]] - hDnaJ peptide-binding domain <br />
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**[[3agx]], [[2qld]] - hDnaJB1 peptide-binding domain <br />
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**[[3agy]], [[3agz]] - hDnaJ peptide-binding domain + HSP70 peptide<br />
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**[[3agy]], [[3agz]] - hDnaJB1 peptide-binding domain + HSP70 peptide<br />
*DnaJ homolog subfamily B member 2
*DnaJ homolog subfamily B member 2
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**[[2lgw]] - hDnaJ J domain - NMR<br />
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**[[2lgw]] - hDnaJB2 J domain - NMR<br />
*DnaJ homolog subfamily B member 8
*DnaJ homolog subfamily B member 8
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**[[2dmx]] - hDnaJ J domain - NMR<br />
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**[[2dmx]] - hDnaJB8 J domain - NMR<br />
*DnaJ homolog subfamily B member 9
*DnaJ homolog subfamily B member 9
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**[[2ctr]] - hDnaJ J domain - NMR<br />
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**[[2ctr]] - hDnaJB9 J domain - NMR<br />
*DnaJ homolog subfamily B member 12
*DnaJ homolog subfamily B member 12
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**[[2ctp]] - hDnaJ J domain - NMR<br />
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**[[2ctp]] - hDnaJB12 J domain - NMR<br />
*DnaJ homolog subfamily C member 1
*DnaJ homolog subfamily C member 1
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**[[2cqq]], [[2cqr]] - hDnaJ DNA-binding domain - NMR<br />
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**[[2cqq]], [[2cqr]] - hDnaJC1 DNA-binding domain - NMR<br />
*DnaJ homolog subfamily C member 2
*DnaJ homolog subfamily C member 2
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**[[2m2e]] - hDnaJ SANT 2 domain - NMR<br />
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**[[2m2e]] - hDnaJC2 SANT 2 domain - NMR<br />
*DnaJ homolog subfamily C member 3
*DnaJ homolog subfamily C member 3
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**[[2y4t]], [[2y4u]] - hDnaJ residues 35-461 <br />
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**[[2y4t]], [[2y4u]] - hDnaJC3 residues 35-461 <br />
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**[[3ieg]] - mDnaJ TPR domain <br />
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**[[3ieg]] - mDnaJC3 TPR domain <br />
*DnaJ homolog subfamily C member 5
*DnaJ homolog subfamily C member 5
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**[[2ctw]] - DnaJ J domain - mouse - NMR<br />
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**[[2ctw]] - DnaJC5 J domain - mouse - NMR<br />
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**[[2n04]], [[2n05]] - hDnaJ N terminal domain - NMR<br />
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**[[2n04]], [[2n05]] - hDnaJC5 N terminal domain - NMR<br />
*DnaJ homolog subfamily C member 10
*DnaJ homolog subfamily C member 10
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**[[3apo]] - mDnaJ <br />
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**[[3apo]] - mDnaJC10 <br />
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**[[5ayk]], [[5ayl]] - mDnaJ (mutant)<br />
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**[[5ayk]], [[5ayl]] - mDnaJC10 (mutant)<br />
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**[[3aps]] - hDnaJ TRX4 domain <br />
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**[[3aps]] - hDnaJC10 TRX4 domain <br />
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**[[3apq]] - mDnaJ TRX4 domain <br />
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**[[3apq]] - mDnaJC10 TRX4 domain <br />
*DnaJ homolog subfamily C member 24
*DnaJ homolog subfamily C member 24
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**[[2l6l]] - hDnaJ - NMR<br />
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**[[2l6l]] - hDnaJC24 - NMR<br />
*DnaJ homolog DnJ-2
*DnaJ homolog DnJ-2
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**[[2qsa]] - DnaJ J domain - ''Caenorhabditis elegans''<br />
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**[[2qsa]] - DnaJ-2 J domain - ''Caenorhabditis elegans''<br />
}}
}}
== References ==
== References ==
<references/>
<references/>

Revision as of 09:22, 1 November 2018

Caption for this structure

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3D structures of DnaJ homolog

Updated on 01-November-2018

References

  1. ↑ Terada K, Mori M. Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. J Biol Chem. 2000 Aug 11;275(32):24728-34. PMID:10816573 doi:http://dx.doi.org/10.1074/jbc.M002021200
  2. ↑ Rauch JN, Gestwicki JE. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014 Jan 17;289(3):1402-14. doi: 10.1074/jbc.M113.521997. Epub 2013 , Dec 5. PMID:24318877 doi:http://dx.doi.org/10.1074/jbc.M113.521997
  3. ↑ Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, Powers R. Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry. 2014 Mar 4;53(8):1360-72. doi: 10.1021/bi401329a. Epub 2014 Feb 19. PMID:24512202 doi:http://dx.doi.org/10.1021/bi401329a

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Michal Harel, Alexander Berchansky

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