DnaJ homolog

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== Structural highlights ==
== Structural highlights ==
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The interaction between DnaB1 and the octapeptide C-terminal of Hsp70 includes various hydrogen bonds, salt bridges and hydrophobic interactions. The octapeptide assumes an extended conformation and forms an antiparallel β sheet with β2 domain I<ref>PMID:20809635</ref>.
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The interaction between DnaJB1 and the octapeptide C-terminal of Hsp70 includes various hydrogen bonds, salt bridges and hydrophobic interactions. The octapeptide assumes an extended conformation and forms an antiparallel β sheet with β2 domain I<ref>PMID:20809635</ref>.
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</StructureSection>

Revision as of 10:18, 4 November 2018

Human DnaJ homolog subfamity B member 1 peptide-binding domain dimer (cyan and green) complex with 3 C-terminal peptides of heat shock protein 70 (pink, magenta, violet) (PDB code 3agy)

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3D structures of DnaJ homolog

Updated on 04-November-2018

References

  1. ↑ Terada K, Mori M. Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. J Biol Chem. 2000 Aug 11;275(32):24728-34. PMID:10816573 doi:http://dx.doi.org/10.1074/jbc.M002021200
  2. ↑ Rauch JN, Gestwicki JE. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014 Jan 17;289(3):1402-14. doi: 10.1074/jbc.M113.521997. Epub 2013 , Dec 5. PMID:24318877 doi:http://dx.doi.org/10.1074/jbc.M113.521997
  3. ↑ Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, Powers R. Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry. 2014 Mar 4;53(8):1360-72. doi: 10.1021/bi401329a. Epub 2014 Feb 19. PMID:24512202 doi:http://dx.doi.org/10.1021/bi401329a
  4. ↑ Suzuki H, Noguchi S, Arakawa H, Tokida T, Hashimoto M, Satow Y. Peptide-binding sites as revealed by the crystal structures of the human Hsp40 Hdj1 C-terminal domain in complex with the octapeptide from human Hsp70. Biochemistry. 2010 Oct 5;49(39):8577-84. Epub 2010 Sep 9. PMID:20809635 doi:10.1021/bi100876n

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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