Nudix hydrolase

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<StructureSection load='1su2' size='350' side='right' caption='Structure of human death-associated protein kinase 1 catalytic domain complex with ATP analog (PDB entry [[1jkl]])' scene=''>
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__TOC__
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== Function ==
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'''Nudix hydrolase''' (NDX) hydrolyses a wide range of organic pyrophosphatases including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps<ref>PMID:16378245</ref>. In prokaryotes the number of Nudix genes varies from 0 to over 30. Mammals have around 24 Nudix genes.
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== Relevance ==
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NDX 7 eliminates potentially toxic nucleotide metabolites from the cell. The NDX of E. coli is named MutT and is able to neutralize the promutagenic compound 7,8-dihydro-oxoguanosine triphosphate<ref>PMID:10373642</ref>.
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== Structural highlights ==
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DAPK1 structure contains a small β sheet N-terminal lobe and a larger helix-rich C-terminal lobe. <scene name='51/517372/Cv/2'>The ATP substrate is bound in a cleft between the two lobes</scene>. <ref>PMID:11573098</ref>
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</StructureSection>
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==3D structures of Nudix hydrolase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[2b0v]], [[3cng]] - NDX - ''Nitrosomonas europaea''<br />
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[[1k2e]], [[1jrk]], [[1k26]] - NDX (mutant) - ''Pyrobaculum aerophilum''<br />
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[[1sjy]], [[1soi]], [[2w4e]] - DrNDX - ''Deinococcus radiodurans''<br />
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[[1su2]] - DrNDX + ATP <br />
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[[1sz3]] - DrNDX + GNP <br />
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[[3fcm]], [[3f6a]] - NDX - ''Clostridium perfringens'' <br />
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[[3qsj]] - NDX - ''Alicyclobacillus acidocaldarius''<br />
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[[3r03]] - NDX - ''Rhodospirillum rubrum'' <br />
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[[2azw]], [[2fml]] - NDX - ''Enterococcus faecalis''<br />
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[[2b06]], [[2pqv]] - NDX - ''Streptococcus pneumoniae'' <br />
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[[3exq]] - NDX - ''Lactobacillus brevis''<br />
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[[3i9x]] - NDX - ''Listeria innocua''<br />
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[[3id9]], [[3smd]] - NDX - ''Bacillus thuringiensis''<br />
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[[4dyw]] - NDX - ''Burkholderia pseudomallei''<br />
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== References ==
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<references/>
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[[Category:Topic Page]]

Revision as of 10:51, 4 November 2018

Structure of human death-associated protein kinase 1 catalytic domain complex with ATP analog (PDB entry 1jkl)

Drag the structure with the mouse to rotate

3D structures of Nudix hydrolase

Updated on 04-November-2018


2b0v, 3cng - NDX - Nitrosomonas europaea
1k2e, 1jrk, 1k26 - NDX (mutant) - Pyrobaculum aerophilum
1sjy, 1soi, 2w4e - DrNDX - Deinococcus radiodurans
1su2 - DrNDX + ATP
1sz3 - DrNDX + GNP
3fcm, 3f6a - NDX - Clostridium perfringens
3qsj - NDX - Alicyclobacillus acidocaldarius
3r03 - NDX - Rhodospirillum rubrum
2azw, 2fml - NDX - Enterococcus faecalis
2b06, 2pqv - NDX - Streptococcus pneumoniae
3exq - NDX - Lactobacillus brevis
3i9x - NDX - Listeria innocua
3id9, 3smd - NDX - Bacillus thuringiensis
4dyw - NDX - Burkholderia pseudomallei

References

  1. ↑ McLennan AG. The Nudix hydrolase superfamily. Cell Mol Life Sci. 2006 Jan;63(2):123-43. doi: 10.1007/s00018-005-5386-7. PMID:16378245 doi:http://dx.doi.org/10.1007/s00018-005-5386-7
  2. ↑ McLennan AG. The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review). Int J Mol Med. 1999 Jul;4(1):79-89. PMID:10373642
  3. ↑ Tereshko V, Teplova M, Brunzelle J, Watterson DM, Egli M. Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. Nat Struct Biol. 2001 Oct;8(10):899-907. PMID:11573098 doi:10.1038/nsb1001-899

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Tihitina Y Aytenfisu

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